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2011, ISBN: 9783211094273

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Details zum Buch
Metallointercalators
Autor:
Titel:
ISBN-Nummer:

9783211094273


A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

Detailangaben zum Buch - Metallointercalators


EAN (ISBN-13): 9783211094273
ISBN (ISBN-10): 321109427X
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: Springer Vienna
427 Seiten
Gewicht: 0,811 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 2009-05-05T16:14:41+02:00 (Berlin)
Detailseite zuletzt geändert am 2024-01-14T12:42:05+01:00 (Berlin)
ISBN/EAN: 9783211094273

ISBN - alternative Schreibweisen:
3-211-09427-X, 978-3-211-09427-3
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: jan aldrich, janice, ald, will wright
Titel des Buches: technique, synthesis, interactions between, wright, probe aufnahmen

Daten vom Verlag:

Autor/in: Janice Aldrich-Wright
Titel: Metallointercalators - Synthesis and Techniques to Probe Their Interactions with Biomolecules
Verlag: Springer; Springer Wien
427 Seiten
Erscheinungsjahr: 2011-04-07
Vienna
Gedruckt / Hergestellt in Niederlande.
Sprache: Englisch
160,49 € (DE)
164,99 € (AT)
177,00 CHF (CH)
POD
XXVIII, 427 p.

BB; Hardcover, Softcover / Chemie/Anorganische Chemie; Anorganische Chemie; Verstehen; Biomolecular drug design; Inorganic Chemistry; Metallointercalator probe techniques; Metallointercalator synthesis; Metallointercalators; Physical Chemistry; Inorganic Chemistry; Pharmacy; Biochemistry; Physical Chemistry; Spectroscopy; Pharmazie, Apotheke; Biochemie; Physikalische Chemie; Spektroskopie, Spektrochemie, Massenspektrometrie; EA; BC

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

Introduction.- Synthesis:Platinum Intercalating Complexes; Binuclear Platinum Complexes;Binuclear Ruthenium and Platinum Intercalating Complexes; Sequence Selective Intercalating Complexes; Targeting and Improving Transport, Cucurbit[n]uril, Cylcodextrin and Dendrimers.- Techniques to Probe Interactions with Biomolecules:Introduction to NMR; DNA-NMR; PGSE-NMR; DNA ESI-MS; Investigating Binding Interactions using Linear Dichromism and Circular Dichromism; Flourescence Spectroscopy; Confocal Microscopy; Implementation of synchotron X-ray microscopy for investigations of the cellular uptake and cellular metabolism of metallointercalators; Biomolecular Helical Structure; Viscosity, TGA and Dialysis; Microarrays; Cytotoxicity-Cell lines; Antibacterical activity; Animal testing.

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.


Provides a detailed exposition on the propaedeutics and techniques illustrated with cogent examples Includes supplementary material: sn.pub/extras

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