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Thiosemicarbazone Iron Chelator - Yu Yu#Des Richardson
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Yu Yu#Des Richardson:
Thiosemicarbazone Iron Chelator - neues Buch

ISBN: 9783844386769

ID: 143707097

Previous studies demonstrated that thiosemicarbazone iron chelator possessed potent and selective anti-cancer activity. In this study, the in vitro and in vivo anti-tumor efficacy and tolerability of 2-benzoylpyridine thiosemicarbazone (BpT) iron chelators were examined. The BpT chelators were tested against human lung cancer cells in vitro and tumor xenografts in mice. The toxicity of Bp44mT and its effects on the expression of iron-regulated molecules involved in growth and cell cycle control were investigated. The results shown demonstrate the anti-tumor activity of the orally-active Bp44mT chelator, which was well tolerated in vivo. Furthermore, the cytotoxicity of thiosemicarbazones is likely to be mediated, in part, through their redox activity and effects on multiple thiol-containing systems. In terms of signal transduction, iron chelation may influence the MAPK signaling pathways via the thioredoxin-ASK1 signalosome. These results emphasize the importance of redox-activity of thiosemicarbazone chelators. Considering their potent anti-tumor activity, these investigations facilitate the future development of promising thiosemicarbazone iron chelators as anti-cancer agents. Evaluation of the anti-cancer activity and mechanisms of action Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, LAP Lambert Academic Publishing

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THIOSEMICARBAZONE IRON CHELATOR - Yu Yu
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Yu Yu:
THIOSEMICARBAZONE IRON CHELATOR - Taschenbuch

ISBN: 9783844386769

[ED: Taschenbuch], [PU: LAP Lambert Acad. Publ.], Neuware - Previous studies demonstrated that thiosemicarbazone iron chelator possessed potent and selective anti-cancer activity. In this study, the in vitro and in vivo anti-tumor efficacy and tolerability of 2-benzoylpyridine thiosemicarbazone (BpT) iron chelators were examined. The BpT chelators were tested against human lung cancer cells in vitro and tumor xenografts in mice. The toxicity of Bp44mT and its effects on the expression of iron-regulated molecules involved in growth and cell cycle control were investigated. The results shown demonstrate the anti-tumor activity of the orally-active Bp44mT chelator, which was well tolerated in vivo. Furthermore, the cytotoxicity of thiosemicarbazones is likely to be mediated, in part, through their redox activity and effects on multiple thiol-containing systems. In terms of signal transduction, iron chelation may influence the MAPK signaling pathways via the thioredoxin-ASK1 signalosome. These results emphasize the importance of redox-activity of thiosemicarbazone chelators. Considering their potent anti-tumor activity, these investigations facilitate the future development of promising thiosemicarbazone iron chelators as anti-cancer agents., [SC: 0.00]

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THIOSEMICARBAZONE IRON CHELATOR - Yu Yu
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Yu Yu:
THIOSEMICARBAZONE IRON CHELATOR - Taschenbuch

ISBN: 9783844386769

[ED: Taschenbuch], [PU: LAP Lambert Acad. Publ.], Neuware - Previous studies demonstrated that thiosemicarbazone iron chelator possessed potent and selective anti-cancer activity. In this study, the in vitro and in vivo anti-tumor efficacy and tolerability of 2-benzoylpyridine thiosemicarbazone (BpT) iron chelators were examined. The BpT chelators were tested against human lung cancer cells in vitro and tumor xenografts in mice. The toxicity of Bp44mT and its effects on the expression of iron-regulated molecules involved in growth and cell cycle control were investigated. The results shown demonstrate the anti-tumor activity of the orally-active Bp44mT chelator, which was well tolerated in vivo. Furthermore, the cytotoxicity of thiosemicarbazones is likely to be mediated, in part, through their redox activity and effects on multiple thiol-containing systems. In terms of signal transduction, iron chelation may influence the MAPK signaling pathways via the thioredoxin-ASK1 signalosome. These results emphasize the importance of redox-activity of thiosemicarbazone chelators. Considering their potent anti-tumor activity, these investigations facilitate the future development of promising thiosemicarbazone iron chelators as anti-cancer agents., [SC: 0.00]

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THIOSEMICARBAZONE IRON CHELATOR - Yu, Yu / Richardson, Des
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Yu, Yu / Richardson, Des:
THIOSEMICARBAZONE IRON CHELATOR - Taschenbuch

2011, ISBN: 3844386769

Gebundene Ausgabe, ID: 10722475

Evaluation of the anti-cancer activity and mechanisms of action - Buch, gebundene Ausgabe, 220 S., Beilagen: Paperback, Erschienen: 2011 LAP Lambert Acad. Publ.

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Thiosemicarbazone Iron Chelator - W Yu
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W Yu:
Thiosemicarbazone Iron Chelator - Taschenbuch

ISBN: 9783844386769

Paperback, [PU: LAP Lambert Academic Publishing], Medicine

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