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Nuclear and cytoplasmic control of the DNA damage checkpoint - A new way of looking at cell cycle control
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Nuclear and cytoplasmic control of the DNA damage checkpoint - A new way of looking at cell cycle control - Taschenbuch

2009, ISBN: 9783838302775

[ED: Taschenbuch / Paperback], [PU: LAP Lambert Academic Publishing], Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, non-proteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1-Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell., [SC: 0.00], Neuware, gewerbliches Angebot, 220 mm, [GW: 259g]

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Nuclear and cytoplasmic control of the DNA damage checkpoint - Farokh Dotiwala
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Nuclear and cytoplasmic control of the DNA damage checkpoint - neues Buch

ISBN: 9783838302775

ID: 2778c0697fb1c223022bb0d313e26595

A new way of looking at cell cycle control Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, non-proteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1-Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-8383-0277-5, LAP Lambert Academic Publishing

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Nuclear and cytoplasmic control of the DNA damage checkpoint - Farokh Dotiwala
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Farokh Dotiwala:
Nuclear and cytoplasmic control of the DNA damage checkpoint - neues Buch

ISBN: 9783838302775

ID: 151152000

Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, non-proteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1-Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell. A new way of looking at cell cycle control Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, LAP Lambert Academic Publishing

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Nuclear and cytoplasmic control of the DNA damage checkpoint als Buch von Farokh Dotiwala - Farokh Dotiwala
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ISBN: 9783838302775

ID: 426675427

Nuclear and cytoplasmic control of the DNA damage checkpoint:A new way of looking at cell cycle control Farokh Dotiwala Nuclear and cytoplasmic control of the DNA damage checkpoint:A new way of looking at cell cycle control Farokh Dotiwala Bücher > Wissenschaft > Biologie, LAP Lambert Academic Publishing

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Nuclear and cytoplasmic control of the DNA damage checkpoint A new way of looking at cell cycle control - Dotiwala, Farokh
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Dotiwala, Farokh:
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2015, ISBN: 383830277X

ID: A6910058

Kartoniert / Broschiert, mit Schutzumschlag neu, [PU:LAP Lambert Academic Publishing]

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