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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - Jalpeshkumar Bhavsar
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Jalpeshkumar Bhavsar:
Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - Taschenbuch

ISBN: 9783659137501

ID: 9783659137501

The formulation with deduction of acid secretion Famotidine is histamine H2 receptor antagonist. It has bioavailability of 40 to 45% and it has shorter plasma half life of 2.5 to 3.5 hrs. The effective treatment of erosive esophagitis and Zolinger-Elisons syndrome requires administration of 20 mg of Famotidine 4 times a day. A conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations thus a sustained release dosage form of famotidine is desirable. Direct access to the systemic circulation bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Moreover, the buccal route is easily accessible, has a good patient compliance and can be used in patients who can t swallow. Bilayer buccal tablet was prepared by using mucoadhesive polymer combination of Sodium CMC and Carbopol934P, by direct compression with backing layer of Ethyl cellulose. The optimized formulation F1 had given release of 102.57% in 8hrs and it had optimum swelling, mucoadhesive property and permeation from buccal mucosa. It also had desired drug release kinetics and found to be stable for the period of 1 month. Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine: Famotidine is histamine H2 receptor antagonist. It has bioavailability of 40 to 45% and it has shorter plasma half life of 2.5 to 3.5 hrs. The effective treatment of erosive esophagitis and Zolinger-Elisons syndrome requires administration of 20 mg of Famotidine 4 times a day. A conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations thus a sustained release dosage form of famotidine is desirable. Direct access to the systemic circulation bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Moreover, the buccal route is easily accessible, has a good patient compliance and can be used in patients who can t swallow. Bilayer buccal tablet was prepared by using mucoadhesive polymer combination of Sodium CMC and Carbopol934P, by direct compression with backing layer of Ethyl cellulose. The optimized formulation F1 had given release of 102.57% in 8hrs and it had optimum swelling, mucoadhesive property and permeation from buccal mucosa. It also had desired drug release kinetics and found to be stable for the period of 1 month., LAP Lambert Academic Publishing

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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - Jalpeshkumar Bhavsar
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Jalpeshkumar Bhavsar:
Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - neues Buch

ISBN: 9783659137501

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Famotidine is histamine H2 receptor antagonist. It has bioavailability of 40 to 45% and it has shorter plasma half life of 2.5 to 3.5 hrs. The effective treatment of erosive esophagitis and Zolinger-Elisons syndrome requires administration of 20 mg of Famotidine 4 times a day. A conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations; thus a sustained release dosage form of famotidine is desirable. Direct access to the systemic circulation bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Moreover, the buccal route is easily accessible, has a good patient compliance and can be used in patients who can t swallow. Bilayer buccal tablet was prepared by using mucoadhesive polymer combination of Sodium CMC and Carbopol934P, by direct compression with backing layer of Ethyl cellulose. The optimized formulation F1 had given release of 102.57% in 8hrs and it had optimum swelling, mucoadhesive property and permeation from buccal mucosa. It also had desired drug release kinetics and found to be stable for the period of 1 month. Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Medizin / Pharmazie

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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine als Buch von Jalpeshkumar Bhavsar, Mukesh Patel, Natvarlal Patel - Jalpeshkumar Bhavsar, Mukesh Patel, Natvarlal Patel
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Jalpeshkumar Bhavsar, Mukesh Patel, Natvarlal Patel:
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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine:The formulation with deduction of acid secretion Jalpeshkumar Bhavsar, Mukesh Patel, Natvarlal Patel Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine:The formulation with deduction of acid secretion Jalpeshkumar Bhavsar, Mukesh Patel, Natvarlal Patel Bücher > Wissenschaft > Medizin, LAP Lambert Academic Publishing

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Formulation and in Vitro Evaluation of Buccal Tablet of Famotidine - Jalpeshkumar Bhavsar
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Jalpeshkumar Bhavsar:
Formulation and in Vitro Evaluation of Buccal Tablet of Famotidine - Taschenbuch

ISBN: 9783659137501

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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine
Autor:

Bhavsar, Jalpeshkumar / Patel, Mukesh / Patel, Natvarlal

Titel:

Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine

ISBN-Nummer:

Detailangaben zum Buch - Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine


EAN (ISBN-13): 9783659137501
ISBN (ISBN-10): 3659137502
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2012
Herausgeber: LAP Lambert Academic Publishing

Buch in der Datenbank seit 18.02.2009 14:22:14
Buch zuletzt gefunden am 25.02.2017 17:04:06
ISBN/EAN: 9783659137501

ISBN - alternative Schreibweisen:
3-659-13750-2, 978-3-659-13750-1


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