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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and  -Helix Mimetics as Modulators of Dormancy Survival Regulator - Zhang, Guangtao
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Taschenbuch

2011, ISBN: 9783639309690

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal., [SC: 0.00], Neuware, gewerbliches Angebot

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and  -Helix Mimetics as Modulators of Dormancy Survival Regulator
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Development of Bisubstrate Analog Inhibitors of Cholera Toxin and -Helix Mimetics as Modulators of Dormancy Survival Regulator - Taschenbuch

2011, ISBN: 9783639309690

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal., [SC: 0.00], Neuware, gewerbliches Angebot

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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ISBN: 9783639309690

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Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 M. It could serve as a promising drug to treat cholera. The second project is to use -helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal. Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Chemie / Organische Chemie, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Guangtao Zhang:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR als Buch von Guangtao Zhang - gebunden oder broschiert

ISBN: 9783639309690

ID: 227634691

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR:Development of Bisubstrate Analog Inhibitors of Cholera Toxin and a-Helix Mimetics as Modulators of Dormancy Survival Regulator Guangtao Zhang Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR:Development of Bisubstrate Analog Inhibitors of Cholera Toxin and a-Helix Mimetics as Modulators of Dormancy Survival Regulator Guangtao Zhang Bücher > Wissenschaft > Chemie, VDM Verlag

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Zhang, Guangtao
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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Taschenbuch

2011, ISBN: 3639309693

Gebundene Ausgabe, ID: 10284024

Development of Bisubstrate Analog Inhibitors of Cholera Toxin and a-Helix Mimetics as Modulators of Dormancy Survival Regulator - Buch, gebundene Ausgabe, 160 S., Beilagen: Paperback, Erschienen: 2011 VDM Verlag, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Details zum Buch
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR
Autor:

Zhang, Guangtao

Titel:

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR

ISBN-Nummer:

Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 µM. It could serve as a promising drug to treat cholera. The second project is to use a-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

Detailangaben zum Buch - Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR


EAN (ISBN-13): 9783639309690
ISBN (ISBN-10): 3639309693
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2011
Herausgeber: VDM Verlag Dr. Müller

Buch in der Datenbank seit 01.07.2009 15:06:36
Buch zuletzt gefunden am 14.05.2017 23:38:21
ISBN/EAN: 9783639309690

ISBN - alternative Schreibweisen:
3-639-30969-3, 978-3-639-30969-0


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