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2012, ISBN: 9783527330157
Gebunden, 256 Seiten, 250mm x 175mm x 18mm, Sprache(n): eng Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of… Mehr…
2012, ISBN: 9783527330157
Gebundene Ausgabe
Series Editor: Mannhold, Raimund, Series Editor: Kubinyi, Hugo, Series Editor: Folkers, Gerd, Wiley-VCH, Gebundene Ausgabe, Auflage: 1. 256 Seiten, Publiziert: 2012-08-22T00:00:01Z, Produ… Mehr…
ISBN: 9783527330157
*Bioisosteres in Medicinal Chem* - 1. Auflage / gebundene Ausgabe für 211.49 € / Aus dem Bereich: Bücher, Wissenschaft, Chemie Medien > Bücher nein Buch (gebunden) Hardcover;Naturwissensc… Mehr…
2012, ISBN: 3527330151
[EAN: 9783527330157], Neubuch, [PU: Wiley-VCH], Books
ISBN: 9783527330157
hardback, [PU: Wiley-VCH, Weinheim]
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As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.
With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Detailangaben zum Buch - Bioisosteres in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry, 54, Band 54)
EAN (ISBN-13): 9783527330157
ISBN (ISBN-10): 3527330151
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2012
Herausgeber: Brown, Nathan, Wiley-VCH
237 Seiten
Gewicht: 0,638 kg
Sprache: Englisch
Buch in der Datenbank seit 2008-03-08T07:09:28+01:00 (Berlin)
Detailseite zuletzt geändert am 2023-12-19T23:57:51+01:00 (Berlin)
ISBN/EAN: 9783527330157
ISBN - alternative Schreibweisen:
3-527-33015-1, 978-3-527-33015-7
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: nath, nathan brown, wiley vch verlag gmbh, hugo kubinyi, gerd folkers
Titel des Buches: hugo, brown, principles chemistry, chem
Daten vom Verlag:
Autor/in: Nathan Brown
Titel: Methods and Principles in Medicinal Chemistry; Bioisosteres in Medicinal Chemistry
Verlag: Wiley-VCH; Wiley-VCH
238 Seiten
Erscheinungsjahr: 2012-08-22
Gedruckt / Hergestellt in Singapur.
Gewicht: 0,624 kg
Sprache: Englisch
162,00 € (DE)
166,60 € (AT)
Available
170mm x 240mm x 16mm
BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Biochemie u. Chemische Biologie; Biochemistry (Chemical Biology); Chemie; Chemistry; Computational Chemistry & Molecular Modeling; Computational Chemistry u. Molecular Modeling; Drug Discovery & Development; Medizinische Chemie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Biochemie u. Chemische Biologie; Computational Chemistry u. Molecular Modeling
PREFACE PART ONE: Principles BIOISOSTERISM IN MEDICINAL CHEMISTRY Introduction Isosterism Bioisosterism Bioisosterism in Lead Optimization Conclusions CLASSICAL BIOISOSTERES Introduction Historical Background Classical Bioisosteres Nonclassical Bioisosteres Summary CONSEQUENCES OF BIOISOSTERIC REPLACEMENT Introduction Bioisosteric Groupings to Improve Permeability Bioisosteric Groupings to Lower Intrinsic Clearance Bioisosteric Groupings to Improve Target Potency Conclusions and Future Perspectives PART TWO: Data BIOSTER: A DATABASE OF BIOISOSTERES AND BIOANALOGUES Introduction Historical Overview and the Development of BIOSTER Description of BIOSTER Database Examples Applications Summary Appendix MINING THE CAMBRIDGE STRUCTURAL DATABASE FOR BIOISOSTERES Introduction The Cambridge Structural Database The Cambridge Structural Database System The Relevance of the CSD to Drug Discovery Assessing Bioisosteres: Conformational Aspects Assessing Bioisosteres: Nonbonded Interactions Finding Bioisosteres in the CSD: Scaffold Hopping and Fragment Linking A Case Study: Bioisosterism of 1H-Tetrazole and Carboxylic Acid Groups Conclusions MINING FOR CONTEXT-SENSITIVE BIOISOSTERIC REPLACEMENTS IN LARGE CHEMICAL DATABASES Introduction Definitions Background Materials and Methods Results and Discussion Conclusions PART THREE: Methods PHYSICOCHEMICAL PROPERTIES Introduction Methods to Identify Bioisosteric Analogues Descriptors to Characterize Properties of Substituents and Spacers Classical Methods for Navigation in the Substituent Space Tools to Identify Bioisosteric Groups Based on Similarity in Their Properties Conclusions MOLECULAR TOPOLOGY Introduction Controlled Fuzziness Graph Theory Data Mining Topological Pharmacophores Reduced Graphs Summary MOLECULAR SHAPE Methods Applications Future Prospects PROTEIN STRUCTURE Introduction Database of Ligand - Protein Complexes Generation of Ideas for Bioisosteres Context-Specific Bioisostere Generation Using Structure to Understand Common Bioisosteric Replacements Conclusions PART FOUR: Applications THE DRUG GURU PROJECT Introduction Implementation of Drug Guru Bioisosteres Application of Drug Guru Quantitative Assessment of Drug Guru Transformations Related Work Summary: The Abbott Experience with the Drug Guru Project BIOISOSTERES OF AN NPY-Y5 ANTAGONIST Introduction Background Potential Bioisostere Approaches Template Molecule Preparation Database Molecule Preparation Alignment and Scoring Results and Monomer Selection Synthesis and Screening Discussion SAR and Developability Optimization Summary and Conclusion PERSPECTIVES FROM MEDICINAL CHEMISTRY Introduction Pragmatic Bioisostere Replacement in Medicinal Chemistry: A Software Maker.s Viewpoint The Role of Quantum Chemistry in Bioisostere Prediction Learn from ''Naturally Drug-Like'' Compounds Bioisosterism at the University of SheffieldWeitere, andere Bücher, die diesem Buch sehr ähnlich sein könnten:
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9783527654321 Bioisosteres in Medicinal Chemistry (Gerd Folkers, Hugo Kubinyi, Nathan Brown, Raimund Mannhold)
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