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Optimization in Drug Discovery
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ISBN: 1617374997

ID: 10798515132

[EAN: 9781617374999], Neubuch, [PU: Humana Press Inc.], ZHENGYIN YAN,GARY W. CALDWELL,PHARMACY,PHARMACOLOGY, Paperback. 420 pages. Dimensions: 9.1in. x 6.5in. x 1.0in.Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. At present, parallel synthesis combining with high-throughput screening has made it easier to generate highly potent compounds (i. e. , hits). However, to be a potential drug, a hit must have drug-like characteristics in addition to potency, which include optimal physicochemical properties, reasonable ph- macokinetic parameters, and good safety profiles. Therefore, research tools must be available in drug discovery to rapidly screen for compounds with favorable drug-like properties, and thus adequate resources can be directed to projects with high potential. Optimization in Drug Discovery: In Vitro Methods is a compilation of detailed experimental protocols necessary for setting up a variety of assays important in compound evaluation. A total of 25 chapters, contributed by many experts in their research areas, cover a wide spectrum of subjects including physicochemical properties, abso- tion, plasma binding, metabolism, drug interactions, and toxicity. A good pharmacokinetic profile has long been recognized as an imp- tant drug-like characteristic. Pharmacokinetic parameters are affected by many properties of drug molecules such as physicochemical nature, abso- tion, metabolic stability, and so on. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN.

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Optimization in Drug Discovery (Paperback)
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2010, ISBN: 1617374997

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[EAN: 9781617374999], Neubuch, [PU: Humana Press Inc., United States], Language: English . Brand New Book ***** Print on Demand *****.Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. At present, parallel synthesis combining with high-throughput screening has made it easier to generate highly potent compounds (i. e. , hits). However, to be a potential drug, a hit must have drug-like characteristics in addition to potency, which include optimal physicochemical properties, reasonable ph- macokinetic parameters, and good safety profiles. Therefore, research tools must be available in drug discovery to rapidly screen for compounds with favorable drug-like properties, and thus adequate resources can be directed to projects with high potential.Optimization in Drug Discovery: In Vitro Methods is a compilation of detailed experimental protocols necessary for setting up a variety of assays important in compound evaluation. A total of 25 chapters, contributed by many experts in their research areas, cover a wide spectrum of subjects including physicochemical properties, abso- tion, plasma binding, metabolism, drug interactions, and toxicity. A good pharmacokinetic profile has long been recognized as an imp- tant drug-like characteristic. Pharmacokinetic parameters are affected by many properties of drug molecules such as physicochemical nature, abso- tion, metabolic stability, and so on.

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Optimization in Drug Discovery (Methods in Pharmacology and Toxicology) - Zhengyin Yan
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Zhengyin Yan:
Optimization in Drug Discovery (Methods in Pharmacology and Toxicology) - Taschenbuch

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Optimization in Drug Discovery - Zhengyin Yan; Gary W. Caldwell
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Optimization in Drug Discovery - Taschenbuch

ISBN: 9781617374999

ID: 9781617374999

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Optimization in Drug Discovery

A panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort.

Detailangaben zum Buch - Optimization in Drug Discovery


EAN (ISBN-13): 9781617374999
ISBN (ISBN-10): 1617374997
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: SPRINGER VERLAG GMBH
436 Seiten
Gewicht: 0,635 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 11.06.2012 03:57:57
Buch zuletzt gefunden am 23.10.2017 19:17:45
ISBN/EAN: 9781617374999

ISBN - alternative Schreibweisen:
1-61737-499-7, 978-1-61737-499-9


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