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Cell Death Signaling in Cancer Biology and Treatment - Daniel E. Johnson
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Cell Death Signaling in Cancer Biology and Treatment - neues Buch

ISBN: 9781461458463

[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed. Defects in cell death pathways promote tumor development and progression, with potentially devastating consequences for cancer patients. Greater understanding of the defects occurring in cancer cells, and the unique characteristics of tumors which can make them vulnerable to cell death stimuli, offers tremendous opportunities for developing novel and effective anti-cancer therapies. In Cell Death in Cancer Biology and Treatment leading experts in the field provide a wealth of up-to-date knowledge regarding the molecular mechanisms and cell biological processes that control cell death. Each chapter also highlights recent advances in the translation of basic research findings into clinical trials. Beginning and established investigators alike will benefit from the thorough presentations of the most promising avenues for future development of cell death-based, anti-cancer strategies and agents. The volume begins with a detailed description of many of the cell death defects that have been identified in human tumor specimens. The unique bioenergetics of cancer cells, and the influence of the tumor microenvironment, autophagy, and cellular microRNAs on cancer cell death are then discussed, along with current progress in targeting these distinctive features and processes. Additional chapters describe recent advances, and the therapeutic benefits of targeting DNA repair pathways, protein chaperones, sphingolipid signaling, Bcl-2 family members, IAPs, death receptor signaling, the proteasome, and survival signaling emanating from the PI3K/AKT and RAS/RAF/MEK/ERK pathways. Finally, recent discoveries are presented regarding interactions between the immune system and dying cancer cells and the potential for optimizing these interactions to maximize anti-cancer activities. In summary, Cell Death in Cancer Biology and Treatment will be a valuable resource for scientists interested in cutting-edge understanding of aberrant cell death in cancer cells, and the multitude of innovative molecular targeting approaches that are actively being pursued to achieve selective activation of cell death in human malignancies. -, [SC: 0.00]

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Cell Death Signaling in Cancer Biology and Treatment | Johnson - Buch - Daniel Johnson - Daniel Johnson
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Cell Death Signaling in Cancer Biology and Treatment | Johnson - Buch - Daniel Johnson - neues Buch

ISBN: 9781461458463

ID: 11440737

Von Daniel Johnson: A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death sign...; Weitere Fachgebiete > Chemie, Biowissenschaften, Agrarwissenschaften > Entwicklungsbiologie > Zellbiologie (Zytologie), Springer-Verlag New York

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Cell Death Signaling in Cancer Biology and Treatment - Daniel Johnson
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Daniel Johnson:
Cell Death Signaling in Cancer Biology and Treatment - neues Buch

ISBN: 9781461458463

ID: 9781461458463

Life Sciences; Cell Biology; Apoptosis; Cancer Research Cancer, Cancer Biology, Cancer Therapy, Cell Death, Johnson, Oncogenesis Books Book, Springer Science+Business Media

Neues Buch Springer.com
Discussing both preclinical and clinical approaches to targeted attacks on tumor cells, this is a key contribution to the fight against cancer, sharing cutting-edge research on the molecular and biological processes regulating cell death in malignant tumo Versandkosten: EUR 0.00
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Cell Death Signaling in Cancer Biology and Treatment - Johnson, Daniel E. (Herausgeber)
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Johnson, Daniel E. (Herausgeber):
Cell Death Signaling in Cancer Biology and Treatment - gebunden oder broschiert

2013, ISBN: 1461458463

ID: A20272692

Gebundene Ausgabe Krebs (Krankheit), Tumor / Krebs, Biologie / Zellbiologie, Zellbiologie, Zelle (biologisch) / Zellbiologie, mit Schutzumschlag neu, [PU:Springer-Verlag GmbH]

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Cell Death Signaling in Cancer Biology and Treatment - Daniel E. Johnson
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Daniel E. Johnson:
Cell Death Signaling in Cancer Biology and Treatment - gebunden oder broschiert

2012, ISBN: 9781461458463

ID: 24787996

Hardcover, Buch, [PU: Springer-Verlag New York Inc.]

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Details zum Buch
Cell Death Signaling in Cancer Biology and Treatment
Autor:

Daniel E. Johnson

Titel:
ISBN-Nummer:

Detailangaben zum Buch - Cell Death Signaling in Cancer Biology and Treatment


EAN (ISBN-13): 9781461458463
ISBN (ISBN-10): 1461458463
Gebundene Ausgabe
Erscheinungsjahr: 2013
Herausgeber: Springer-Verlag GmbH
406 Seiten
Gewicht: 0,757 kg
Sprache: Englisch

Buch in der Datenbank seit 24.06.2007 10:31:47
Buch zuletzt gefunden am 22.09.2017 05:01:55
ISBN/EAN: 9781461458463

ISBN - alternative Schreibweisen:
1-4614-5846-3, 978-1-4614-5846-3


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