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Evolutionary Biology - John S. Torday
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John S. Torday:
Evolutionary Biology - neues Buch

ISBN: 9781118130421

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Cell-Cell Communication, and Complex Disease InhaltsangabePreface xiAbout the Authors xiii1 THE CELLULAR ORIGIN OF VERTEBRATES 1The Origins of Unicellular Life on Earth 1Prokaryotes versus Eukaryotes 4Coevolution of traits 5Cholesterol Facilitates Lipid Rafts for Cell– Cell Communication 7The Endomembrane System 9The Cellular Mechanism of Evolution 10Why Evolve 11Cell– Cell Communication and Aging 122 REDUCING LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES 17Hormonal Acceleration of Lung Development 17Neutral Lipid Traffi cking and Lung Evolution 19Other Examples of Cellular Cooperativity 23Summary 243 A CELL– MOLECULAR STRATEGY FOR SOLVING THE EVOLUTIONARY PUZZLE 25Rationale for Cell– Molecular Evolution 25Mechanism of Mammalian Lung Development 28Avian Lung Structure– Function Relationship: The Exception that Proves the Rule 32Does Ontogeny Recapitulate Phylogeny The Role of PTHrP in Lung Development 32Interrelationship between PTHrP, Development, Physiology, and Repair: Is Repair a Recapitulation of Ontogeny and Phylogeny 334 THE EVOLUTION OF CELL– CELL COMMUNICATION 35Cell– Cell Communication as the Mechanistic Basis for Evolutionary Biology 36The Darwinian Biologic Spacetime Continuum and Einstein’ s Vision of the Universe 37Reverse Engineering of Physiologic Traits as a Portal for Viewing Evolution 38Cell– Cell Communication as the Basis for the Evolution of Metazoans 41Understanding Lung Evolution from the Middle Out 42The Cell– Cell Communication Model of Lung Evolution Traces Contemporary Phenotypes Back to Ancestral Phenotypes 43Predictive Value of the Lung Cell– Cell Communication Model for Understanding the Evolution of Physiologic Systems 44Sexual Dimorphism of Lung Development: A Case Study in Cell– Cell Communication and Evolutionary Plasticity 46Androgen Affects the Expression of Growth Factors Involved in Lung Development 48Evidence for an Association between Steroid-Resistant/Responsive Phenotypes and Human Lymphocyte Antigen (HLA) Haplotypes 495 HOW TO INTEGRATE CELL-MOLECULAR DEVELOPMENT, HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY BIOLOGY: THE MISSING LINKS 53Neutral Theory versus Intelligent Design 54Internal Selection Theory 54The Counterintuitive Nature of Physiology and Solution to the Dead Sea Scrolls Puzzle 57The Continuum from Microevolution to Macroevolution 58cis Regulation and Adaptive Evolution 69Evolution of cis Regulatory Mechanisms 706 FROM CELL– CELL COMMUNICATION TO THE EVOLUTION OF INTEGRATED PHYSIOLOGY 75Cell– cell Signaling and Alveolar Development: A Reductionist Approach to the Evolution of Physiologic Traits 77An Integrated, Empiric, Middle– Out Approach to Physiology 79A Molecular Evolutionary Link between the Lung and the Kidney 82The Berner Hypothesis and Emergence of the Adipocyte: The Evolutionary Origins of the Lipofi broblast 83Lung Biology as a Cipher for Evolution 85Do Stretch Effects on PTHrP Expression Reflect Its Role in Adapting to Gravity 85Wolff’ s Law Works for Both Bone and Lung 88Functional Relationship between the External and Internal Environments 89An Evolutionary Vertical Integration of the Phylogeny and Ontogeny of the Thyroid 917 EXPLOITING CELL– CELL COMMUNICATION ACROSS SPACETIME TO DECONSTRUCT EVOLUTION 95Somewhere between the Gene and the Phenotype Lies the Process of Evolution 98 TERMS OF THE CELL– CELL COMMUNICATION MODEL FOR EVOLUTION 125This is Not a Just-So Story 126Beyond Genomics 128From Fat Cells to Integrated Physiology 128Molecular Homologies Distinguish between the Evolutionary Forest and Trees 129The Oxygen– Cholesterol– Surfactant– Membrane Connection 130Cholesterol Metabolism as the Data Operating System for Vertebrate Biology 131Translation of Genomics into the Periodic Table for Biology 132Deep Homologies 134Selection Pressure for Cell– Cell Communication: The Key to Understanding Evolution 13510 CELL– CELL COMMUNICATION AS THE BASIS FOR PRACTICING CLINICAL MEDICINE 139Cell– Cell Communication Maintenance and Breakdown Represent Heath and Disease, Respectively 140Cell– Cell Communications as a Framework for Human Evolution 140Canalization, Decanalization, and the Holistic Approach to the Practice of Medicine 141Exploiting Lung Evolution to Prevent and Treat Chronic Lung Disease 141Lung Evolution Explains the Magic of Continuous Positive Airway Pressure 142The Paradox of Infecting the Lung in Order to Treat Lung Disease Caused by Infection 143Exploiting Lung Evolution to Prevent and Treat Smoking-Related Lung Damage 144The Trojan Horse Effect of Canalization 145Impetus for Evolutionary Science as an Integral Part of the Clinical Curriculum 146Application of Evolutionary Science to Bioethics 147Evolutionary Science, a Biologic Periodic Table, and a Unifi ed Theory of Biology 148Summary 149Name Index 151Subject Index 153 Evolutionary Biology: InhaltsangabePreface xiAbout the Authors xiii1 THE CELLULAR ORIGIN OF VERTEBRATES 1The Origins of Unicellular Life on Earth 1Prokaryotes versus Eukaryotes 4Coevolution of traits 5Cholesterol Facilitates Lipid Rafts for Cell– Cell Communication 7The Endomembrane System 9The Cellular Mechanism of Evolution 10Why Evolve 11Cell– Cell Communication and Aging 122 REDUCING LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES 17Hormonal Acceleration of Lung Development 17Neutral Lipid Traffi cking and Lung Evolution 19Other Examples of Cellular Cooperativity 23Summary 243 A CELL– MOLECULAR STRATEGY FOR SOLVING THE EVOLUTIONARY PUZZLE 25Rationale for Cell– Molecular Evolution 25Mechanism of Mammalian Lung Development 28Avian Lung Structure– Function Relationship: The Exception that Proves the Rule 32Does Ontogeny Recapitulate Phylogeny The Role of PTHrP in Lung Development 32Interrelationship between PTHrP, Development, Physiology, and Repair: Is Repair a Recapitulation of Ontogeny and Phylogeny 334 THE EVOLUTION OF CELL– CELL COMMUNICATION 35Cell– Cell Communication as the Mechanistic Basis for Evolutionary Biology 36The Darwinian Biologic Spacetime Continuum and Einstein’ s Vision of the Universe 37Reverse Engineering of Physiologic Traits as a Portal for Viewing Evolution 38Cell– Cell Communication as the Basis for the Evolution of Metazoans 41Understanding Lung Evolution from the Middle Out 42The Cell– Cell Communication Model of Lung Evolution Traces Contemporary Phenotypes Back to Ancestral Phenotypes 43Predictive Value of the Lung Cell– Cell Communication Model for Understanding the Evolution of Physiologic Systems 44Sexual Dimorphism of Lung Development: A Case Study in Cell– Cell Communication and Evolutionary Plasticity 46Androgen Affects the Expression of Growth Factors Involved in Lung Development 48Evidence for an Association between Steroid-Resistant/Responsive Phenotypes and Human Lymphocyte Antigen (HLA) Haplotypes 495 HOW TO INTEGRATE CELL-MOLECULAR DEVELOPMENT, HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY BIOLOGY: THE MISSING LINKS 53Neutral Theory versus Intelligent Design 54Internal Selection Theory 54The Counterintuitive Nature of Physiology and Solution to the Dead Sea Scrolls Puzzle 57The Continuum from Microevolution to Macroevolution 58cis Regulation and Adaptive Evolution 69Evolution of cis Regulatory Mechanisms 706 FROM CELL– CELL COMMUNICATION TO THE EVOLUTION OF INTEGRATED PHYSIOLOGY 75Cell– cell Signaling and Alveolar Development: A Reductionist Approach to the Evolution of Physiologic Traits 77An Integrated, Empiric, Middle– Out Approach to Physiology 79A Molecular Evolutionary Link between the Lung and the Kidney 82The Berner Hypothesis and Emergence of the Adipocyte: The Evolutionary Origins of the Lipofi broblast 83Lung Biology as a Cipher for Evolution 85Do Stretch Effects on PTHrP Expression Reflect Its Role in Adapting to Gravity 85Wolff’ s Law Works for Both Bone and Lung 88Functional Relationship between the External and Internal Environments 89An Evolutionary Vertical Integration of the Phylogeny and Ontogeny of the Thyroid 917 EXPLOITING CELL– CELL COMMUNICATION ACROSS SPACETIME TO DECONSTRUCT EVOLUTION 95Somewhere between the Gene and the Phenotype Lies the Process of Evolution 98 TERMS OF THE CELL– CELL COMMUNICATION MODEL FOR EVOLUTION 125This is Not a Just-So Story 126Beyond Genomics 128From Fat Cells to Integrated Physiology 128Molecular Homologies Distinguish between the Evolutionary Forest and Trees 129The Oxygen– Cholesterol– Surfactant– Membrane Connection 130Cholesterol Metabolism as the Data Operating System for Vertebrate Biology 131Translation of Genomics into the Periodic Table for Biology 132Deep Homologies 134Selection Pressure for Cell– Cell Communication: The Key to Understanding Evolution 13510 CELL– CELL COMMUNICATION AS THE BASIS FOR PRACTICING CLINICAL MEDICINE 139Cell– Cell Communication Maintenance and Breakdown Represent Heath and Disease, Respectively 140Cell– Cell Communications as a Framework for Human Evolution 140Canalization, Decanalization, and the Holistic Approach to the Practice of Medicine 141Exploiting Lung Evolution to Prevent and Treat Chronic Lung Disease 141Lung Evolution Explains the Magic of Continuous Positive Airway Pressure 142The Paradox of Infecting the Lung in Order to Treat Lung Disease Caused by Infection 143Exploiting Lung Evolution to Prevent and Treat Smoking-Related Lung Damage 144The Trojan Horse Effect of Canalization 145Impetus for Evolutionary Science as an Integral Part of the Clinical Curriculum 146Application of Evolutionary Science to Bioethics 147Evolutionary Science, a Biologic Periodic Table, and a Unifi ed Theory of Biology 148Summary 149Name Index 151Subject Index 153 Biowissenschaften Cell Biology Life Sciences Medical Science Medizin Molecular Evolution Molekulare Evolution Physiologie Physiology Zellbiologie, John Wiley & Sons

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Evolutionary Biology - John S. Torday#Virender K. Rehan
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2012, ISBN: 9781118130421

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An integrative view of the evolution of genetics and the naturalworld Even in this advanced age of genomics, the evolutionary processof unicellular and multicellular organisms is continually indebate. Evolutionary Biology, Cell-Cell Communication, andComplex Disease challenges current wisdom by using physiology topresent an integrative view of the nature, origins, and evolutionof fundamental biological systems. Providing a deeper understanding of the way genes relate to thetraits of living organisms, this book offers useful informationapplying evolutionary biology, functional genomics, and cellcommunication studies to complex disease. Examining the 4.5billion-year evolution process from environment adaptations tocell-cell communication to communication of genetic information forreproduction, Evolutionary Biology hones in on the ´´why and how´´ ofevolution by uniquely focusing on the cell as the smallest unit ofbiologic structure and function. Based on empirically derived data rather than associationstudies, Evolutionary Biology covers: * A model for forming testable hypotheses in complex diseasestudies * The integrating role played by the evolution of metabolism,especially lipid metabolism * The evolutionary continuum from development to homeostasis * Regeneration and aging mediated by signaling molecules Ambitious and game-changing Evolutionary Biology suggests thatbiology began as a mechanism for reducing energy within the cell,defying the Second Law of Thermodynamics. An ideal text for thoseinterested in forward thinking scientific study, the insightspresented in Evolutionary Biology help practitioners effectivelycomprehend the evolutionary process. Cell-Cell Communication, and Complex Disease eBook PDF 15.03.2012 eBooks>Fremdsprachige eBooks>Englische eBooks>Sach- & Fachthemen>Medizin, John Wiley & Sons, .201

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Evolutionary Biology : Cell-Cell Communication, and Complex Disease - Xiaolan Qiu
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An integrative view of the evolution of genetics and the natural world Even in this advanced age of genomics, the evolutionary process of unicellular and multicellular organisms is continually in debate. Evolutionary Biology, Cell Cell Communication, and Complex Disease challenges current wisdom by using physiology to present an integrative view of the nature, origins, and evolution of fundamental biological systems.Providing a deeper understanding of the way genes relate to the traits of living organisms, this book offers useful information applying evolutionary biology, functional genomics, and cell communication studies to complex disease. Examining the 4.5 billion-year evolution process from environment adaptations to cell-cell communication to communication of genetic information for reproduction, Evolutionary Biology hones in on the "why and how" of evolution by uniquely focusing on the cell as the smallest unit of biologic structure and function.Based on empirically derived data rather than association studies, Evolutionary Biology covers:A model for forming testable hypotheses in complex disease studiesThe integrating role played by the evolution of metabolism, especially lipid metabolismThe evolutionary continuum from development to homeostasisRegeneration and aging mediated by signaling moleculesAmbitious and game-changing Evolutionary Biology suggests that biology began as a mechanism for reducing energy within the cell, defying the Second Law of Thermodynamics. An ideal text for those interested in forward thinking scientific study, the insights presented in Evolutionary Biology help practitioners effectively comprehend the evolutionary process.; PDF \ Xiaolan Qiu; Scientific, Technical and Medical > Biology, life sciences > Life sciences: general issues > Evoluti, Wiley

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Evolutionary Biology - Cell-Cell Communication, and Complex Disease - Torday, John S.; Rehan, Virender K.
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Torday, John S.; Rehan, Virender K.:
Evolutionary Biology - Cell-Cell Communication, and Complex Disease - neues Buch

2012, ISBN: 1118130421

ID: 9781118130421

In englischer Sprache. Verlag: John Wiley & Sons, Chapter 1. On the Cellular Origin of Vertebrates. Chapter 2. Reducing Lung Physiology to its Molecular Phenotypes. Chapter 3. A Cell-Molecular Strategy to Solving the Evolutionary Puzzle. Chapter 4. On the Evolution of Cell-Cell Communication. Chapter 5. How to Integrate Cell-Molecular Development, Homeostasis, Ecology and Evolutionary Biology - The "Missing Links". Chapter 6. From Cell-Cell Communication to the Evolution of Integrated Physiology. Chapter 7. Exploiting Cell-Cell Communication Across Space-Time to Deconstruct Evolution. Chapter 8. The Periodic Table of Biology. Chapter 9. Value Added by Thinking in Terms of the Cell-Cell Communication Model for Evolution. Chapter 10. Cell-Cell Communication Maintenance and Breakdown Represent "Health" and "Disease", Respectively. PC-PDF, 200 Seiten, 200 Seiten, 1., Auflage, [GR: 9672 - Nonbooks, PBS / Biologie/Mikrobiologie], [SW: - Mikrobiologie (nicht-medizinisch) ], [Ausgabe: 1][PU:John Wiley & Sons]

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Evolutionary Biology - John S. Torday;  Virender K. Rehan
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John S. Torday; Virender K. Rehan:
Evolutionary Biology - Erstausgabe

2012, ISBN: 9781118130421

ID: 26064665

Cell-Cell Communication, and Complex Disease, [ED: 1], Auflage, eBook Download (PDF), eBooks, [PU: Wiley-Blackwell]

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