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The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms?such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules?has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enable allied health services,basic sciences,biochemistry,biological sciences,biology,biology and life sciences,chemistry,evolution,genetics,library and information science Evolution, Humana Press
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Combinatorial Library Methods and Protocols (Methods in Molecular Biology, Volume 201) - gebunden oder broschiert
2002, ISBN: 0896039803
[EAN: 9780896039803], Gebraucht, sehr guter Zustand, [PU: Humana, USA], UOK, COMBINATORIAL LIBRARY METHODS AND PROTOCOLS (METHODS IN MOLECULAR BIOLOGY, VOLUME 201); LISA BELLAVANCE ENGLISH; ENCODED LIBRARIES; SYNTHESIS OF DNA-BINDING POLYAMIDES, RECEPTORS, Medical|Pharmacy, Science|Chemistry|General, 0896039803. Hardcover, from closed pharmaceutical company library. Minor bump on one corner. Lending record shows this book has been borrowed three times only. 383 pages, index, illustrated with charts, tables and diagrams. A novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of just such combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR.Sections include: Contents as new, clean, tight and bright.
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Lisa English and a panel of expert chemical researchers have collected in Combinatorial Library Methods and Protocols a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of just such combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR. Books, Science and Nature, Combinatorial Library: Methods and Protocols Books>Science and Nature, Humana Press
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Combinatorial library methods and protocols. (Methods in molecular biology; v.201) - gebunden oder broschiert
2002, ISBN: 9780896039803
Humana Press Inc., 2002. Hardbound. New Book. Hardbound. The building of combinatorial libraries of gene targets for drug interaction has been made possible by the growth of genome sequencing projects. This volume explores both chemical synthesis of combinatorial libraries and the information management issues raised by such synthesis. English (BD Bioscience) first presents 12 chapters of strategies for synthesis and quality control. Three chapters look at purification and screening of combinatorial libraries. The final five contributions examine computational approaches to combinatorial library design. (2002 Ringgold, Inc., Portland, OR), Humana Press Inc., 2002
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Detailangaben zum Buch - Combinatorial Library Methods and Protocols
EAN (ISBN-13): 9780896039803
ISBN (ISBN-10): 0896039803
Herausgeber: SPRINGER VERLAG GMBH
Gewicht: 0,748 kg
Buch in der Datenbank seit 16.12.2007 22:18:56
Buch zuletzt gefunden am 09.01.2018 14:04:07
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