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Malignant Liver Tumours: Basic Concepts and Clinical Management (Falk Symposium) - F. Berr, J. Bruix, J. Hauss, Ch. Wittekind, J. Wands
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[SR: 4868226], Hardcover, [EAN: 9780792387794], Springer, Springer, Book, [PU: Springer], Springer, Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines. , 227205, Gastroenterology, 227203, Internal Medicine, 265542, Medicine, 173514, Medical Books, 1000, Subjects, 283155, Books, 227212, Oncology, 227203, Internal Medicine, 265542, Medicine, 173514, Medical Books, 1000, Subjects, 283155, Books, 14145, Digestive Organs, 14116, Diseases, 227692, Pathology, 227203, Internal Medicine, 265542, Medicine, 173514, Medical Books, 1000, Subjects, 283155, Books, 689738011, Gastroenterology, 689725011, Clinical, 689674011, Medicine, 468228, Medicine & Health Sciences, 465600, New, Used & Rental Textbooks, 2349030011, Specialty Boutique, 283155, Books, 689753011, Oncology, 689725011, Clinical, 689674011, Medicine, 468228, Medicine & Health Sciences, 465600, New, Used & Rental Textbooks, 2349030011, Specialty Boutique, 283155, Books

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Malignant Liver Tumours: Basic Concepts and Clinical Management (Falk Symposium) - F. Berr, J. Bruix, J. Hauss, Ch. Wittekind, J. Wands
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Hardcover, [EAN: 9780792387794], Springer, Springer, Book, [PU: Springer], Springer, 270860, Oncology, 270847, Diseases & Disorders, 270842, Internal Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 270867, Gastroenterology, 270842, Internal Medicine, 270767, Medical & Healthcare Practitioners, 74, Health, Family & Lifestyle, 1025612, Subjects, 266239, Books, 922572, Medical Sciences A-Z, 922574, Accident & Emergency Medicine, 270911, Anaesthetics, 270844, Cardiovascular, 922594, Clinical Psychology & Psychotherapy, 922596, Counselling & Therapy, 922606, Dermatology, 922610, Diseases & Disorders, 922632, Elderly Care, 270864, Endocrinology, 922638, ENT, 270928, Forensic Medicine, 270867, Gastroenterology, 922654, Health Psychology, 922664, Neurology, 922676, Ophthalmology, 922678, Orthopaedic & Fractures, 922682, Paediatrics, 922684, Pathology, 922700, Pre-clinical Medicine, 270948, Psychiatry, 922718, Psychotherapy & Clinical Psychology, 922720, Public Health & Preventive Medicine, 922730, Radiology & Medical Imaging, 270889, Renal Medicine, 270890, Respiratory Medicine, 270891, Rheumatology, 922752, Sports Injuries & Medicine, 922754, Surgery, 270892, Urology, 922532, Medicine, 57, Science & Nature, 1025612, Subjects, 266239, Books, 571382, Medical Sciences A-Z, 571384, Anaesthetics, 571400, Cardiovascular, 571334, Diseases & Disorders, 571390, Gynaecology & Obstetrics, 571386, Neurology, 571316, Orthopaedic & Fractures, 571388, Paediatrics, 571362, Pathology, 571392, Psychiatry, 571290, Public Health & Preventive Medicine, 571350, Radiology & Medical Imaging, 571280, Research & Equipment, 571310, Surgery, 564356, Medicine & Nursing, 564334, Scientific, Technical & Medical, 1025612, Subjects, 266239, Books

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Malignant Liver Tumours: Basic Concepts and Clinical Management

Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines.

Detailangaben zum Buch - Malignant Liver Tumours: Basic Concepts and Clinical Management


EAN (ISBN-13): 9780792387794
ISBN (ISBN-10): 0792387791
Gebundene Ausgabe
Erscheinungsjahr: 2003
Herausgeber: SPRINGER VERLAG GMBH
211 Seiten
Gewicht: 0,481 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 24.01.2008 03:33:53
Buch zuletzt gefunden am 28.07.2017 18:46:47
ISBN/EAN: 9780792387794

ISBN - alternative Schreibweisen:
0-7923-8779-1, 978-0-7923-8779-4


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