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2007, ISBN: 9780470516478
Molecular Pharmacology, Buch, Hardcover, G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions rangin… Mehr…
2007, ISBN: 047051647X
[EAN: 9780470516478], Neubuch, [PU: John Wiley & Sons], MEDICAL NURSING PHARMACOLOGY PHARMACY BIOWISSENSCHAFTEN CELL & MOLECULAR BIOLOGY CHEMIE CHEMISTRY LIFE SCIENCES SCIENCE MEDIZIN MOL… Mehr…
2007
ISBN: 9780470516478
Gebundene Ausgabe
[ED: Gebunden], [PU: John Wiley & Sons], G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions rangin… Mehr…
2007, ISBN: 9780470516478
Molecular Pharmacology, Buch, Hardcover, [PU: John Wiley & Sons Inc], John Wiley & Sons Inc, 2007
2008, ISBN: 047051647X
[EAN: 9780470516478], Gebraucht, wie neu, [PU: Wiley], Like New, Books
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Detailangaben zum Buch - G Protein-coupled Receptors
EAN (ISBN-13): 9780470516478
ISBN (ISBN-10): 047051647X
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2007
Herausgeber: John Wiley & Sons Inc
252 Seiten
Gewicht: 0,687 kg
Sprache: eng/Englisch
Buch in der Datenbank seit 2008-02-22T22:59:15+01:00 (Berlin)
Detailseite zuletzt geändert am 2024-02-22T17:23:15+01:00 (Berlin)
ISBN/EAN: 9780470516478
ISBN - alternative Schreibweisen:
0-470-51647-X, 978-0-470-51647-8
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: bengt, mentzer, vauquelin, even georges, von below, von see, mentz
Titel des Buches: pharmacology, vauquelin
Daten vom Verlag:
Autor/in: Georges Vauquelin; Bengt von Mentzer
Titel: G Protein-coupled Receptors - Molecular Pharmacology
Verlag: John Wiley & Sons
264 Seiten
Erscheinungsjahr: 2007-11-23
Gewicht: 0,706 kg
Sprache: Englisch
165,00 € (DE)
Not available (reason unspecified)
168mm x 244mm x 17mm
BB; GB; Hardcover, Softcover / Biologie/Mikrobiologie; Mikrobiologie (nicht-medizinisch); Molekularbiologie; Pharmakologie
FOREWORD A) CHEMICAL MESSENGERS AND THE CELL MEMBRANE A.1. Endocrine signalling by hormones. A.2. The nervous system and synaptic signalling by neurotransmitters. SMALL MOLECULE NEUROTRANSMITTERS NEUROPEPTIDES A.3. Paracrine signalling by local chemical messengers. A.4. Hydrophobicity: effect on release and transport of messengers. A.5. Membrane proteins and membrane receptors. A.6. Ligand receptor interactions. B) RADIOLIGAND BINDING STUDIES B.1. Technical aspects of radioligand binding. B.2. Saturation binding. B.3. Competition binding. B.5. Regional distribution of receptors. C) FUNCTIONAL STUDIES C.1. Dose-response curves and associated problems. C.2. From receptor-occupation to stimulus and response. FROM RECEPTOR OCCUPATION TO STIMULUS FROM STIMULUS TO RESPONSE: LINEAR RELATIONSHIP FROM STIMULUS TO RESPONSE: NON-LINEAR RELATIONSHIP C.3. Receptor classification and antagonist affinity. C.4. Pharmacological models. D) G PROTEIN-COUPLED RECEPTORS D.1. From receptor to response: introduction to GPCRs. D.2. GPCR structure. D.3. Ligand interaction with family A, B, C receptors. LIGAND INTERACTION WITH FAMILY A RECEPTORS LIGAND INTERACTION WITH FAMILY B RECEPTORS LIGAND INTERACTION WITH FAMILY C RECEPTORS D.4. Receptor activation. D.5. Activated GPCRs: interaction with G proteins. TECHNIQUES TO STUDY G -PROTEIN COUPLING PREFERENCE DIVERGENCE OF INTRACELLULAR SIGNALLING D.6. Activated GPCRs: phosphorylation and internalisation. RECEPTOR PHOSPHORYLATION b-ARRESTIN BINDING MEDIATE GPCR ENDOCYTOSIS. MECHANISMS TO TERMINATE SIGNALLING. D.7. b-Arrestin- binding and MAP kinase activation. D.8. GPCR dimerisation and association with other proteins. INTRODUCTORY COMMENTS GPCR DIMERISATION. GPCR INTERACTION WITH OTHER MEMBRANE RECEPTORS. GPCR INTERACTION WITH OTHER MEMBRANE PROTEINS. GPCR INTERACTION WITH CYTOPLASMIC PROTEINS D.9. Early models for GPCR activation. D.10. Restricted GPCR mobility and G protein coupling. MEMBRANE COMPARTIMENTALISATION RESTRICTED GPCR- G PROTEIN COUPLING: EFFECTOR ACTIVITY D.11. Spontaneous receptor- G protein coupling. MODELS INVERSE AGONISM D.12. Interaction of two G proteins with one activated receptor state. FUSION PROTEINS BETWEEN GPCRS AND G PROTEINS D.13. Multiple receptor conformations. "AGONIST TRAFFICKING": WHAT DO MODELS PREDICT? EXPERIMENTAL "EVIDENCE" FOR AGONIST TRAFFICKING: POTENTIAL PITFALLS MULTISTATE RECEPTORS: LIGAND- MEDIATED SEQUENTIAL CHANGES IN RECEPTOR CONFORMATION MULTIPLE RECEPTOR STATES RELATED TO TRUNCATION, COVALENT MODIFICATION AND MUTATION D.14. Multistate receptors and multiple ligand binding sites. THE GENERAL ALLOSTERIC TERNARY COMPLEX MODEL EXOGENOUS AND ENDOGENOUS ALLOSTERIC MODULATORS ALLOSTERIC PHENOMENA AT GPCR: DETECTION BY RADIOLIGAND BINDING DETECTION OF ALLOSTERIC PHENOMENA AT GPCR BY FUNCTIONAL ASSAYS USEFULNESS OF ALLOSTERIC MODULATORS D.15. "Competitive", "non-competitive "and "insurmountable" antagonism. CO-INCUBATION, NO RECEPTOR RESERVE ANTAGONIST PREINCUBATION, NO RECEPTOR RESERVE D.16. Naturally occurring mutations of GPCRs. E) CONCLUDING REMARKS REFERENCES INDEXWeitere, andere Bücher, die diesem Buch sehr ähnlich sein könnten:
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