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The Unfolded Protein Response and Cellular Stress, Part C - P. Michael Conn
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P. Michael Conn:
The Unfolded Protein Response and Cellular Stress, Part C - neues Buch

2011, ISBN: 9780123859280

ID: 226590086

The observation that the living cell contains a mechanism to sense and correct the accumulation of unfolded (or incorrectly folded) proteins in the endoplasmic reticulum was formidable in organizing thoughts about cellular integration. This mechanism both halts further protein synthesis and promotes the production of chaperone proteins that act to relieve this problem. If this problem cannot be corrected, the mechanism can initiate programmed cell death. Aspects of this unfolded protein response (UPR) are conserved from yeast to man, an observation that suggests a key role in the process of maintaining a living cell. The UPR presents a way of understanding cellular regulation, a mechanism for disease and a therapeutic opportunity. This third of three parts provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. Authors were selected based on research contributions in the area about which they have written and based on their ability to describe their methodological contribution in a clear and reproducible way. They have been encouraged to make use of graphics, comparisons to other methods, and to provide tricks and approaches not revealed in prior publications that make it possible to adapt methods to other systems. The Unfolded Protein Response and Cellular Stress, Part C Bücher > Fremdsprachige Bücher > Englische Bücher gebundene Ausgabe 01.04.2011, Elsevier LTD, Oxford, .201

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Methods in enzymology - Conn, P. Michael
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Methods in enzymology - neues Buch

ISBN: 9780123859280

ID: 739195

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. Science Science eBook, Elsevier Science

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The Unfolded Protein Response and Cellular Stress, Part C - Conn, P. Michael
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Conn, P. Michael:
The Unfolded Protein Response and Cellular Stress, Part C - neues Buch

2011, ISBN: 012385928X

ID: A12665617

Broschiert MEDICAL / General, SCIENCE / Life Sciences / Molecular Biology, mit Schutzumschlag neu, [PU:Elsevier LTD, Oxford]

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The Unfolded Protein Response and Cellular Stress, Part C
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The Unfolded Protein Response and Cellular Stress, Part C - Erstausgabe

2011, ISBN: 9780123859280

Gebundene Ausgabe, ID: 17171178

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The Unfolded Protein Response and Cellular Stress - Saurabh Jha; Dr. P. Michael Conn
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Saurabh Jha; Dr. P. Michael Conn:
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2011, ISBN: 9780123859280

ID: 17171178

Hardcover, Buch, [PU: Academic Press Inc]

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The Unfolded Protein Response and Cellular Stress, Part C

The observation that the living cell contains a mechanism to sense and correct the accumulation of unfolded (or incorrectly folded) proteins in the endoplasmic reticulum was formidable in organizing thoughts about cellular integration. This mechanism both halts further protein synthesis and promotes the production of chaperone proteins that act to relieve this problem. If this problem cannot be corrected, the mechanism can initiate programmed cell death. Aspects of this unfolded protein response (UPR) are conserved from yeast to man, an observation that suggests a key role in the process of maintaining a living cell. The UPR presents a way of understanding cellular regulation, a mechanism for disease and a therapeutic opportunity. This third of three parts provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. Authors were selected based on research contributions in the area about which they have written and based on their ability to describe their methodological contribution in a clear and reproducible way. They have been encouraged to make use of graphics, comparisons to other methods, and to provide tricks and approaches not revealed in prior publications that make it possible to adapt methods to other systems.

Detailangaben zum Buch - The Unfolded Protein Response and Cellular Stress, Part C


EAN (ISBN-13): 9780123859280
ISBN (ISBN-10): 012385928X
Gebundene Ausgabe
Erscheinungsjahr: 2011
Herausgeber: Elsevier LTD, Oxford
407 Seiten
Gewicht: 0,896 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 06.03.2007 07:31:33
Buch zuletzt gefunden am 11.11.2017 19:52:17
ISBN/EAN: 9780123859280

ISBN - alternative Schreibweisen:
0-12-385928-X, 978-0-12-385928-0


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