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In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus - Das Choudhury, Jyotirmoy / Kumar, Suresh
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Das Choudhury, Jyotirmoy / Kumar, Suresh:
In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus - Taschenbuch

ISBN: 3659281662

ID: 22517568951

[EAN: 9783659281662], Neubuch, Publisher/Verlag: LAP Lambert Academic Publishing | To Prevent Cancer Induce Apoptosis | An essential oil from a lemon grass variety of Cymbopogon flexuosus (CFO) and its major chemical constituent sesquiterpene isointermedeol (ISO) were investigated for their ability to induce apoptosis in human leukaemia HL-60 cells because dysregulation of apoptosis is the hallmark of cancer cells. CFO and ISO inhibited cell proliferation with 48 h IC50 of 30 and 20 g/ml, respectively. Both induced concentration dependent strong and early apoptosis as measured by various end-points, e.g. annexinV binding, DNA laddering, apoptotic bodies formation and an increase in hypo diploid sub-G0 DNA content during the early 6 h period of study. This could be because of early surge in ROS formation with concurrent loss of mitochondrial membrane potential observed. Both CFO and ISO activated apical death receptors TNFR1, DR4 and caspase-8 activity. Simultaneously, both increased the expression of mitochondrial cytochrome c protein with its concomitant release to cytosol leading to caspase-9 activation, suggesting thereby the involvement of both the intrinsic and extrinsic pathways of apoptosis. | Format: Paperback | Language/Sprache: english | 272 pp

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In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus - Jyotirmoy Das Choudhury
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Jyotirmoy Das Choudhury:
In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus - Taschenbuch

2012, ISBN: 3659281662

ID: 22516655477

[EAN: 9783659281662], Neubuch, [PU: LAP Lambert Academic Publishing Okt 2012], Neuware - An essential oil from a lemon grass variety of Cymbopogon flexuosus (CFO) and its major chemical constituent sesquiterpene isointermedeol (ISO) were investigated for their ability to induce apoptosis in human leukaemia HL-60 cells because dysregulation of apoptosis is the hallmark of cancer cells. CFO and ISO inhibited cell proliferation with 48 h IC50 of 30 and 20 g/ml, respectively. Both induced concentration dependent strong and early apoptosis as measured by various end-points, e.g. annexinV binding, DNA laddering, apoptotic bodies formation and an increase in hypo diploid sub-G0 DNA content during the early 6 h period of study. This could be because of early surge in ROS formation with concurrent loss of mitochondrial membrane potential observed. Both CFO and ISO activated apical death receptors TNFR1, DR4 and caspase-8 activity. Simultaneously, both increased the expression of mitochondrial cytochrome c protein with its concomitant release to cytosol leading to caspase-9 activation, suggesting thereby the involvement of both the intrinsic and extrinsic pathways of apoptosis. 272 pp. Englisch

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In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus als Buch von Jyotirmoy Das Choudhury, Suresh Kumar, Shashi Bhushan - Jyotirmoy Das Choudhury, Suresh Kumar, Shashi Bhushan
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ISBN: 9783659281662

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In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus:To Prevent Cancer Induce Apoptosis Jyotirmoy Das Choudhury, Suresh Kumar, Shashi Bhushan In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus:To Prevent Cancer Induce Apoptosis Jyotirmoy Das Choudhury, Suresh Kumar, Shashi Bhushan Bücher > Wissenschaft > Medizin, LAP Lambert Academic Publishing

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In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus als Buch von Jyotirmoy Das Choudhury, Suresh Kumar, Shashi Bhushan - LAP Lambert Academic Publishing
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In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus ab 79 EURO To Prevent Cancer Induce Apoptosis In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus ab 79 EURO To Prevent Cancer Induce Apoptosis Bücher > Wissenschaft > Medizin

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In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus: To Prevent Cancer Induce Apoptosis - Das Choudhury, Jyotirmoy; Kumar, Suresh; Bhushan, Shashi
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Das Choudhury, Jyotirmoy; Kumar, Suresh; Bhushan, Shashi:
In vitro Evaluation of Anti Cancer Activity of Cymbopogon flexuosus: To Prevent Cancer Induce Apoptosis - Taschenbuch

2012, ISBN: 3659281662

ID: 21175760131

[EAN: 9783659281662], Neubuch, [PU: Lap Lambert Academic Publishing], This item is printed on demand for shipment within 3 working days.

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