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Stereoselective Synthesis of Biologically Active Novel Heterocycles - in Drug Discovery - Alluri, Sesha Sridevi / Ganguly, A. K.
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Alluri, Sesha Sridevi / Ganguly, A. K.:
Stereoselective Synthesis of Biologically Active Novel Heterocycles - in Drug Discovery - Taschenbuch

2012, ISBN: 9783659260476

[ED: Taschenbuch / Paperback], [PU: LAP Lambert Academic Publishing], Many of the drugs in human medicine are chiral because they bind to enzymes and receptors to elicit biological activity. Both enzymes and receptors are chiral and therefore in a chiral drug molecule one of the enantiomer is more active than the other. Most of the drugs are also heterocyclic in nature. In the present study we have conceived ideas of what heterocycles might show activity against a particular disease based on their bindings at enzyme or receptor level and investigated the role of chirality in these molecules. Novel synthetic methodologies were developed for the enantioselective synthesis of these heterocycles possessing chiral centers and we believe these synthetic methodologies will be useful for the synthesis of other drugs. Using the above general concepts we have synthesized novel enantiomerically pure chiral heterocylces such as 5-aryl oxindoles, which have shown potent activity as progesterone receptor antagonists, spiro-oxindoles, for possible use as cancer therapeutics, ortho-ortho disubstituted bipheyl lactams, for possible implications in CNS and cancer therapy, and conformationally restricted sulfonamides as HIV-1 protease inhibitors for treatment of AIDS., DE, [SC: 0.00], Neuware, gewerbliches Angebot, H: 220mm, B: 150mm, 288, Selbstabholung und Barzahlung, PayPal, offene Rechnung, Banküberweisung, Internationaler Versand

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Stereoselective Synthesis of Biologically Active Novel Heterocycles - Sesha Sridevi Alluri
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Sesha Sridevi Alluri:
Stereoselective Synthesis of Biologically Active Novel Heterocycles - Taschenbuch

2012, ISBN: 3659260479

ID: 10409379164

[EAN: 9783659260476], Neubuch, [PU: LAP Lambert Academic Publishing Okt 2012], This item is printed on demand - Print on Demand Titel. Neuware - Many of the drugs in human medicine are chiral because they bind to enzymes and receptors to elicit biological activity. Both enzymes and receptors are chiral and therefore in a chiral drug molecule one of the enantiomer is more active than the other. Most of the drugs are also heterocyclic in nature. In the present study we have conceived ideas of what heterocycles might show activity against a particular disease based on their bindings at enzyme or receptor level and investigated the role of chirality in these molecules. Novel synthetic methodologies were developed for the enantioselective synthesis of these heterocycles possessing chiral centers and we believe these synthetic methodologies will be useful for the synthesis of other drugs. Using the above general concepts we have synthesized novel enantiomerically pure chiral heterocylces such as 5-aryl oxindoles, which have shown potent activity as progesterone receptor antagonists, spiro-oxindoles, for possible use as cancer therapeutics, ortho-ortho disubstituted bipheyl lactams, for possible implications in CNS and cancer therapy, and conformationally restricted sulfonamides as HIV-1 protease inhibitors for treatment of AIDS. 288 pp. Englisch

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Stereoselective Synthesis of Biologically Active Novel Heterocycles: in Drug Discovery - Alluri, Sesha Sridevi; Ganguly, A. K.
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Alluri, Sesha Sridevi; Ganguly, A. K.:
Stereoselective Synthesis of Biologically Active Novel Heterocycles: in Drug Discovery - Taschenbuch

2012, ISBN: 3659260479

ID: 13788579395

[EAN: 9783659260476], Neubuch, [PU: LAP LAMBERT Academic Publishing], This item is printed on demand for shipment within 3 working days.

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Stereoselective Synthesis of Biologically Active Novel Heterocycles - Alluri, Sesha Sridevi / Ganguly, A. K.
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
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Alluri, Sesha Sridevi / Ganguly, A. K.:
Stereoselective Synthesis of Biologically Active Novel Heterocycles - Taschenbuch

ISBN: 3659260479

Gebundene Ausgabe, ID: 13084945

in Drug Discovery - Buch, gebundene Ausgabe, 288 S., Beilagen: Paperback, Erschienen: 2012 LAP Lambert Academic Publishing

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Stereoselective Synthesis of Biologically Active Novel Heterocycles - Alluri, Sesha Sridevi / Ganguly, A. K.
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Alluri, Sesha Sridevi / Ganguly, A. K.:
Stereoselective Synthesis of Biologically Active Novel Heterocycles - Taschenbuch

2012, ISBN: 3659260479

Gebundene Ausgabe, ID: 13084945

in Drug Discovery - Buch, gebundene Ausgabe, 288 S., Beilagen: Paperback, Erschienen: 2012 LAP Lambert Academic Publishing

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