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Tetrahydrobiopterin and nitric oxide synthase  regulation - Generation and analysis of endothelial-targeted transgenic mouse lines  over-expressing human GTP cyclohydrolase 1 - Alp, Nicholas
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Alp, Nicholas:
Tetrahydrobiopterin and nitric oxide synthase regulation - Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1 - Taschenbuch

2009, ISBN: 9783639164008

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of its cofactor tetrahydrobiopterin (BH4). BH4 bioavailability is limited by oxidative degradation in dysfunctional endothelium, and by alterations in the rate of its biosynthesis, governed by the rate-limiting enzyme GTP cyclohydrolase 1 (GTPCH). In this project novel targeted transgenic mouse lines were generated with endothelial-specific over-expression of human GTPCH. These studies have shown that BH4 bioavailability within the endothelium is essential for maintaining NO synthesis and reducing superoxide production by eNOS in vivo. Modest persistent increases in endothelial cell BH4 concentration by increased biosynthesis are sufficient to maintain NO bioavailability and endothelial function, even in the setting of vascular oxidative stress. These findings suggest that strategies to augment endothelial BH4 levels, either by increased biosynthesis or by reducing BH4 oxidation, may be valuable in preventing and treating vascular disease., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 140, [GW: 200g], Selbstabholung und Barzahlung, PayPal, offene Rechnung, Banküberweisung, Internationaler Versand

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Tetrahydrobiopterin and nitric oxide synthase regulation - Nicholas Alp
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ISBN: 9783639164008

ID: a99b7d8fc5b551de36f7b2029c2aa538

Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of its cofactor tetrahydrobiopterin (BH4). BH4 bioavailability is limited by oxidative degradation in dysfunctional endothelium, and by alterations in the rate of its biosynthesis, governed by the rate-limiting enzyme GTP cyclohydrolase 1 (GTPCH). In this project novel targeted transgenic mouse lines were generated with endothelial-specific over-expression of human GTPCH. These studies have shown that BH4 bioavailability within the endothelium is essential for maintaining NO synthesis and reducing superoxide production by eNOS in vivo. Modest persistent increases in endothelial cell BH4 concentration by increased biosynthesis are sufficient to maintain NO bioavailability and endothelial function, even in the setting of vascular oxidative stress. These findings suggest that strategies to augment endothelial BH4 levels, either by increased biosynthesis or by reducing BH4 oxidation, may be valuable in preventing and treating vascular disease. Buch / Broschur, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Tetrahydrobiopterin and nitric oxide synthase regulation: Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1 - Nicholas Alp
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Nicholas Alp:
Tetrahydrobiopterin and nitric oxide synthase regulation: Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1 - Taschenbuch

ISBN: 9783639164008

ID: 599422284

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Tetrahydrobiopterin and nitric oxide synthase regulation: Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1 - Alp, Nicholas
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Alp, Nicholas:
Tetrahydrobiopterin and nitric oxide synthase regulation: Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1 - Taschenbuch

2009, ISBN: 9783639164008

ID: 640588688

VDM Verlag, 2009-06-05. Paperback. New. Buy with confidence. Excellent Customer Service & Return policy., VDM Verlag, 2009-06-05

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Tetrahydrobiopterin and nitric oxide synthase regulation - Alp, Nicholas
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Alp, Nicholas:
Tetrahydrobiopterin and nitric oxide synthase regulation - Taschenbuch

2009, ISBN: 3639164008

Gebundene Ausgabe, ID: 5285027

Generation and analysis of endothelial-targetedtransgenic mouse lines over-expressing human GTP cyclohydrolase 1 - Buch, gebundene Ausgabe, 140 S., Beilagen: Paperback, Erschienen: 2009 VDM Verlag, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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