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The Ubiquitin System in Health and Disease - Stefan Jentsch
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[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein-protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an -amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals., [SC: 0.00], Neuware, gewerbliches Angebot, 216x155x23 mm, [GW: 391g]

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The Ubiquitin System in Health and Disease - Stefan Jentsch
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Stefan Jentsch:
The Ubiquitin System in Health and Disease - neues Buch

ISBN: 9783540851066

[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein-protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an -amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals., [SC: 0.00], Neuware, gewerbliches Angebot, FixedPrice, [GW: 391g]

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The Ubiquitin System in Health and Disease - STEFAN JENTSCH
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Relié, [EAN: 9783540851066], Springer, Springer, Book, [PU: Springer], Springer, 301130, Thèmes, 689215031, Actu, Politique et Société, 4237308031, Adolescents, 301144, Art, Musique et Cinéma, 301133, Bandes dessinées, 293136011, Beaux livres, 8434456031, Calendriers et Agendas, 302050, Cuisine et Vins, 301147, Dictionnaires, langues et encyclopédies, 301985, Droit, 301135, Entreprise et Bourse, 573312, Érotisme, 406310, Esotérisme et Paranormal, 3961911, Etudes supérieures, 301142, Famille et Bien-être, 301138, Fantasy et Terreur, 689214031, Histoire, 302009, Humour, 301131, Informatique et Internet, 301137, Livres pour enfants, 355635011, Loisirs créatifs, décoration et bricolage, 302004, Manga, 355636011, Nature et animaux, 301997, Religions et Spiritualités, 302042, Romance et littérature sentimentale, 301132, Romans et littérature, 301134, Romans policiers et polars, 12641896031, Santé, Forme et Diététique, 1381962031, Science-Fiction, 301141, Sciences, Techniques et Médecine, 301139, Sciences humaines, 301146, Scolaire et Parascolaire, 301143, Sports et passions, 302051, Tourisme et Voyages, 301061, Livres

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The Ubiquitin System in Health and Disease. Edited by S. Jentsch and B. Haendler. (Ernst Schering Foundation Symposium Proceedings 2008-1). - Jentsch, S. (Ed.) and B. Haendler (Ed.)
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8° (17,5-22,5 cm). Orig.-Pappband. [Hardcover / fest gebunden]. XV, 190 Seiten. Mit 39 Abbildungen. Pappband Neuwertiges Exemplar. / As new. ISBN: 9783540851066 Jentsch, S. (Ed.) and B. Haendler (Ed.): The Ubiquitin System in Health and Disease. Edited by S. Jentsch and B. Haendler. (Ernst Schering Foundation Symposium Proceedings 2008-1). Berlin, Heidelberg & New York: Springer 2009. XV, 190 Seiten. Mit 39 Abbildungen. 8° (17,5-22,5 cm). Orig.-Pappband. [Hardcover / fest gebunden]. gebraucht; wie neu, [PU:Berlin, Heidelberg & New York: Springer]

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The Ubiquitin System in Health and Disease - Jentsch, Stefan (Herausgeber); Haendler, B. (Herausgeber)
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Gebundene Ausgabe Biochemie (Heilmethode), Biomedizin, Medizin / Biomedizin, Gesundheitswesen, mit Schutzumschlag neu, [PU:Springer-Verlag GmbH]

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Details zum Buch
The Ubiquitin System in Health and Disease
Autor:

Stefan Jentsch

Titel:

The Ubiquitin System in Health and Disease

ISBN-Nummer:

The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. Most of the enzymes involved in adding or removing ubiquitin chains have been identified, but often their direct substrate and the type of ubiquitylation remains to be clarified. A better understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention and pave the way for improved therapies. The latest developments in this rapidly moving field are presented in this book.

Detailangaben zum Buch - The Ubiquitin System in Health and Disease


EAN (ISBN-13): 9783540851066
ISBN (ISBN-10): 3540851062
Gebundene Ausgabe
Erscheinungsjahr: 2008
Herausgeber: Springer-Verlag GmbH
191 Seiten
Gewicht: 0,391 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 17.05.2007 11:51:04
Buch zuletzt gefunden am 02.05.2017 22:37:08
ISBN/EAN: 3540851062

ISBN - alternative Schreibweisen:
3-540-85106-2, 978-3-540-85106-6


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