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Reactive Drug Metabolites - Amit S. Kalgutkar|Deepak Dalvie|R. Scott Obach|Dennis A. Smith
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Amit S. Kalgutkar|Deepak Dalvie|R. Scott Obach|Dennis A. Smith:

Reactive Drug Metabolites - gebunden oder broschiert

2012, ISBN: 3527330852

[EAN: 9783527330850], Neubuch, [PU: Wiley-VCH GmbH], CHEMIE MEDIZIN BASIC PHARMACOLOGY CHEMISTRY DRUG DISCOVERY & DEVELOPMENT GRUNDLAGEN DER PHARMAKOLOGIE MEDICAL SCIENCE TOXICOLOGY TOXIK… Mehr…

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Kalgutkar, Amit S.; Dalvie, Deepak; Obach, R. Scott; Smith, Douglas A.; Mannhold, Raimund [Series Editor]; Kubinyi, Hugo [Series Editor]; Folkers, Gerd [Series Editor];:

Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - gebunden oder broschiert

2012, ISBN: 9783527330850

Wiley-VCH, 2012-12-26. Hardcover. Used:Good., Wiley-VCH, 2012-12-26, 0

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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Douglas A. Smith, Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor):
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - gebunden oder broschiert

2012

ISBN: 9783527330850

Wiley-VCH, 2012-12-26. 1. Hardcover. Good., Wiley-VCH, 2012-12-26, 2.5

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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers:
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - gebunden oder broschiert

2012, ISBN: 3527330852

[EAN: 9783527330850], Neubuch, [PU: Wiley VCH 2012-10-24]

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Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith:
Reactive Drug Metabolites - Erstausgabe

2012, ISBN: 9783527330850

Gebundene Ausgabe

Buch, Hardcover, 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2012

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Bibliographische Daten des bestpassenden Buches

Details zum Buch
Reactive Drug Metabolites

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest
pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs.

The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive
and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating
the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented.

Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Detailangaben zum Buch - Reactive Drug Metabolites


EAN (ISBN-13): 9783527330850
ISBN (ISBN-10): 3527330852
Gebundene Ausgabe
Erscheinungsjahr: 2012
Herausgeber: Wiley-VCH
386 Seiten
Gewicht: 1,017 kg
Sprache: Englisch

Buch in der Datenbank seit 2007-04-28T00:39:27+02:00 (Berlin)
Detailseite zuletzt geändert am 2023-04-05T14:49:48+02:00 (Berlin)
ISBN/EAN: 3527330852

ISBN - alternative Schreibweisen:
3-527-33085-2, 978-3-527-33085-0
Alternative Schreibweisen und verwandte Suchbegriffe:
Autor des Buches: scott, deepak, amit, douglas smith, dennis, raimund, hugo kubinyi, gerd folkers, kalg
Titel des Buches: amit


Daten vom Verlag:

Autor/in: Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Titel: Methods and Principles in Medicinal Chemistry; Reactive Drug Metabolites
Verlag: Wiley-VCH; Wiley-VCH
386 Seiten
Erscheinungsjahr: 2012-10-24
Gedruckt / Hergestellt in Singapur.
Gewicht: 1,000 kg
Sprache: Englisch
172,00 € (DE)
Not available (reason unspecified)
170mm x 240mm x 25mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Chemie; Basic Pharmacology; Chemie; Chemistry; Drug Discovery & Development; Grundlagen der Pharmakologie; Medical Science; Medizin; Toxicology; Toxikologie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Toxikologie; Grundlagen der Pharmakologie

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

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