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Reactive Drug Metabolites, Volume 55 - Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers:

Reactive Drug Metabolites, Volume 55 - gebunden oder broschiert

ISBN: 3527330852

[SR: 1752900], Hardcover, [EAN: 9783527330850], Wiley-VCH, Wiley-VCH, Book, [PU: Wiley-VCH], Wiley-VCH, Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training., 13575, Clinical, 13570, Chemistry, 75, Science & Math, 1000, Subjects, 283155, Books, 265544, Pharmacology, 16311581, Cardiovascular, 16311631, Chemistry, 16311601, Clinical, 16311591, Drug Delivery Systems, 227673, Drug Guides, 227661, For Nurses, 227738, For Veterinarians, 16311541, Molecular, 16311571, Neuropsychopharmacology, 265547, Pain Medicine, 16311561, Pharmacodynamics, 265548, Pharmacy, 16311611, Product Development, 16311551, Reference, 265549, Toxicology, 173514, Medical Books, 1000, Subjects, 283155, Books, 689721011, Pharmacology, 689709011, Basic Sciences, 689674011, Medicine, 468228, Medicine & Health Sciences, 465600, New, Used & Rental Textbooks, 2349030011, Specialty Boutique, 283155, Books

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This first comprehensive introduction to the topic discusses the current best practice to manage toxicity risks in new drugs, including an in-depth analysis of the toxicological potential of the top 200 prescription drugs. Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-527-33085-0, Wiley-VCH

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Reactive Drug Metabolites, Volume 55 - Mannhold, Raimund; Kubinyi, Hugo; Folkers, Gerd; Smith, Douglas A.; Dalvie, Deepak; Obach, R. Scott; Kalgutkar, Amit
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ID: 1023284

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training. Medicine Medicine eBook, Wiley

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Smith, Dennis A.;Mannhold, Raimund;Kalgutkar, Amit S.;Dalvie, Deepak;Obach, R. Scott: Reactive Drug Metabolites
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Methods and Principles in Medicinal Chemistry. 1. Auflage Methods and Principles in Medicinal Chemistry. 1. Auflage Bücher > English, International > Gebundene Ausgaben, [PU: Wiley-VCH, Weinheim]

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Details zum Buch
Reactive Drug Metabolites
Autor:

Kalgutkar, Amit S. / Dalvie, Deepak / Obach, R. Scott / Smith, Dennis

Titel:

Reactive Drug Metabolites

ISBN-Nummer:

3527330852

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest
pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs.

The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive
and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating
the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented.

Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Detailangaben zum Buch - Reactive Drug Metabolites


EAN (ISBN-13): 9783527330850
ISBN (ISBN-10): 3527330852
Gebundene Ausgabe
Erscheinungsjahr: 2012
Herausgeber: Wiley VCH Verlag GmbH
386 Seiten
Gewicht: 1,017 kg
Sprache: Englisch

Buch in der Datenbank seit 28.04.2007 00:39:27
Buch zuletzt gefunden am 07.03.2017 22:11:23
ISBN/EAN: 3527330852

ISBN - alternative Schreibweisen:
3-527-33085-2, 978-3-527-33085-0

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