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Mitochondrial DNA, Mitochondria, Disease and Stem Cells - Justin C. St. John
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ISBN: 9781627031011

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This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring`s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next. Mitochondrial DNA, Mitochondria, Disease and Stem Cells: This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring`s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next. SCIENCE / Life Sciences / Cell Biology, Springer-Verlag Gmbh

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Mitochondrial DNA, Mitochondria, Disease and Stem Cells - Justin C. St. John
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9, ISBN: 9781627031011

ID: 203179781627031011

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring's well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mito This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring's well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next. Cytology, Biological Sciences, Mitochondrial DNA, Mitochondria, Disease and Stem Cells~~ Justin C. St. John~~Cytology~~Biological Sciences~~9781627031011, en, Mitochondrial DNA, Mitochondria, Disease and Stem Cells, Justin C. St. John, 9781627031011, Humana Press, 09/26/2012, , , , Humana Press, 09/26/2012

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Mitochondrial DNA, Mitochondria, Disease and Stem Cells - St. John, Justin C.
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St. John, Justin C.:
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2012, ISBN: 1627031014

ID: 9781627031011

In englischer Sprache. Verlag: Humana Press, Professor Justin St. John was awarded his PhD in 1999. In 2000, he was awarded a Mellon Fellowship at the Oregon National Primate Research Center, Oregon, USA. His achievements as an early career scientist led to his rapid promotion to the position of Professor at the University of Warwick (2007). Whilst in the UK, he was funded by the Medical Research Council and received an Endeavour Fellowship to undertake a period of research at Monash Institute of Medical Research where he has been Director of the Centre for Reproduction and Development and a Professor in the Faculty of Nursing, Medicine and Health Sciences at Monash University since November 2009. His research focuses on developing and using specific model systems to understand how mitochondrial DNA is transmitted and replicated. He was the first to demonstrate that sperm mitochondrial DNA could persist in the late stage embryo and thus be transmitted; describe mitochondrial DNA replication events in undifferentiated and differentiating embryonic stem cells; and demonstrate why donor cell mitochondrial DNA is transmitted to embryos and offspring following somatic cell nuclear transfer. He is using these outcomes to develop mini-pig models of mitochondrial DNA disease and reproductive strategies to prevent the transmission of mutant mitochondrial DNA from one generation to the next. He has published in The Lancet, Nature Chemical Biology, Nature Cell Biology, Stem Cells, Journal of Cell Science, and Genetics. PC-PDF, 189 Seiten, X Seiten, 189 Seiten, 1., 2013, [GR: 9677 - Nonbooks, PBS / Biologie/Genetik, Gentechnik], [SW: - DNA], [Ausgabe: 1]

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Mitochondrial DNA, Mitochondria, Disease and Stem Cells - Justin C. St. John
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2013, ISBN: 9781627031011

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2013, ISBN: 9781627031011

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Details zum Buch
Mitochondrial DNA, Mitochondria, Disease and Stem Cells
Autor:

Justin C. St. John

Titel:
ISBN-Nummer:

Detailangaben zum Buch - Mitochondrial DNA, Mitochondria, Disease and Stem Cells


EAN (ISBN-13): 9781627031011
ISBN (ISBN-10): 1627031014
Erscheinungsjahr: 2012
Herausgeber: Humana Press
189 Seiten
Sprache: eng/Englisch

Buch in der Datenbank seit 08.08.2012 05:49:54
Buch zuletzt gefunden am 28.09.2015 10:48:56
ISBN/EAN: 1627031014

ISBN - alternative Schreibweisen:
1-62703-101-4, 978-1-62703-101-1


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