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DNA Methylation, Epigenetics And Metastasis
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ISBN: 9781402036415

ID: 9129287

Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins. Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors "conspire" to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them. In this book, the current directions in the epigenetics of cancer progression and metastasis are comprehensively described. It is now the turn of the reader to take care of the future. Dr Manel Esteller, Director, Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) mesteller@cnio. Books, Science and Geography~~Biology, Life Sciences~~Molecular Biology, DNA Methylation, Epigenetics And Metastasis~~Book~~9781402036415, , , , , , , , , ,, [PU: Springer]

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DNA Methylation, Epigenetics and Metastasis - Manel Esteller
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DNA Methylation, Epigenetics and Metastasis - neues Buch

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[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - Most of the cancer patients die because the tumoral cells do not 'stick' in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors 'conspire' to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them. In this book, the current directions in the epigenetics of cancer progression and metastasis are comprehensively described. It is now the turn of the reader to take care of the future. Dr Manel Esteller, Director, Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) mesteller@cnio., [SC: 0.00], Neuware, gewerbliches Angebot, 156x234x19 mm, [GW: 630g]

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DNA Methylation, Epigenetics and Metastasis
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(*)
DNA Methylation, Epigenetics and Metastasis - neues Buch

ISBN: 9781402036415

ID: 844925889

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis. weltbild.at > Bücher > Wissenschaft & Technik > Medizin & Pharmazie, [PU: Springer]

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DNA Methylation, Epigenetics and Metastasis - Esteller, Manel (Herausgeber)
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2005, ISBN: 1402036418

ID: A4404104

Gebundene Ausgabe DNS (Genetik) - Desoxyribonucleinsäure, Genetik / DNS, Desoxyribonucleinsäure ( DNS (Genetik) ), Erblehre, Genetik, Geschwulst, Krebs (Krankheit) / Geschwulst, Krebs (Krankheit) / Tumor, Neoplasma, Neubildung, Präneoplasie, Tumor, mit Schutzumschlag neu, [PU:Springer-Verlag GmbH]

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DNA Methylation, Epigenetics and Metastasis - Manel Esteller
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Manel Esteller:
DNA Methylation, Epigenetics and Metastasis - gebunden oder broschiert

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Details zum Buch
DNA Methylation, Epigenetics and Metastasis
Autor:

Manel Esteller

Titel:

DNA Methylation, Epigenetics and Metastasis

ISBN-Nummer:

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.

Detailangaben zum Buch - DNA Methylation, Epigenetics and Metastasis


EAN (ISBN-13): 9781402036415
ISBN (ISBN-10): 1402036418
Gebundene Ausgabe
Erscheinungsjahr: 2005
Herausgeber: Springer-Verlag GmbH
310 Seiten
Gewicht: 0,630 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 23.05.2007 23:35:01
Buch zuletzt gefunden am 20.05.2017 14:14:18
ISBN/EAN: 1402036418

ISBN - alternative Schreibweisen:
1-4020-3641-8, 978-1-4020-3641-5


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