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Concepts, Mechanisms, and New Targets for Chemotherapy - Franco M. Muggia (Editor)
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The book contains black-and-white illustrations. Textbooks New Books ~~ Medicine~~ Oncology Concepts-Mechanisms-and-New-Targets-for-Chemotherapy~~Franco-M-Muggia Springer US Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity. Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways. Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers.

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Concepts, Mechanisms, and New Targets for Chemotherapy
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Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity. Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways. Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers. Books, Health and Well Being, Concepts, Mechanisms, and New Targets for Chemotherapy Books>Health and Well Being, Springer US

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Hardback, [PU: Kluwer Academic Publishers], Describes new interconnections between rationally designed and empirically discovered compounds. This book includes a summary of the status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity., Chemotherapy

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Concepts Mechanisms and New Targets for Chemotherapy - Franco M. Muggia
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Concepts Mechanisms and New Targets for Chemotherapy Author :Franco M. Muggia 9780792335252 0792335252, [PU: Kluwer Academic Publishers]

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Concepts, Mechanisms, and New Targets for Chemotherapy

Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity. Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways. Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers.

Detailangaben zum Buch - Concepts, Mechanisms, and New Targets for Chemotherapy


EAN (ISBN-13): 9780792335252
ISBN (ISBN-10): 0792335252
Gebundene Ausgabe
Erscheinungsjahr: 1995
Herausgeber: SPRINGER VERLAG GMBH
256 Seiten
Gewicht: 0,526 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 11.05.2007 08:38:26
Buch zuletzt gefunden am 26.10.2017 17:15:13
ISBN/EAN: 0792335252

ISBN - alternative Schreibweisen:
0-7923-3525-2, 978-0-7923-3525-2


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