Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis ord… Mehr…
Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis orders. How can we identify exogenous ligands mediating the effects of mGluRs? How do these ligands affect the receptor? The author Tobias Noeske presents the establishment of strategies for the identification and optimization of molecules acting as non-competitive anta gonists of group I mGluRs. These strategies ensure high diversity in the identi fied chemotypes not resembling original reference molecules ('scaffold-hop ping'). The detection of new scaffolds, in turn, is divided into two ap proa ches: First the development of pharmacological assays to screen com pounds at a certain target for their bioactivity, and second the evaluation of com pu ter aided methods for the identification of virtual hits to be screened on the pharmacological assays. Promising molecules were optimized regarding bio activity and selectivity, their binding mode investigated and, fi nally, com pared to existing lead compounds. This book addresses scientists in academia and industry working in early stage drug discovery, predominantly in computer aided drug design. Bücher > Fremdsprachige Bücher > Englische Bücher 220 x 150 x 12 mm , AV Akademikerverlag, Taschenbuch, AV Akademikerverlag<
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Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis ord… Mehr…
Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis orders. How can we identify exogenous ligands mediating the effects of mGluRs? How do these ligands affect the receptor? The author Tobias Noeske presents the establishment of strategies for the identification and optimization of molecules acting as non-competitive anta gonists of group I mGluRs. These strategies ensure high diversity in the identi fied chemotypes not resembling original reference molecules ('scaffold-hop ping'). The detection of new scaffolds, in turn, is divided into two ap proa ches: First the development of pharmacological assays to screen com pounds at a certain target for their bioactivity, and second the evaluation of com pu ter aided methods for the identification of virtual hits to be screened on the pharmacological assays. Promising molecules were optimized regarding bio activity and selectivity, their binding mode investigated and, fi nally, com pared to existing lead compounds. This book addresses scientists in academia and industry working in early stage drug discovery, predominantly in computer aided drug design. Buch (fremdspr.) Tobias Noeske Taschenbuch, AV Akademikerverlag, 22.05.2012, AV Akademikerverlag, 2012<
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Noeske, Tobias: Ligand Binding in the Transmembrane Region: of Metabotropic Glutamate Receptors- Practical and Theoretical Investigations Paperback - Taschenbuch
Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis ord… Mehr…
Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis orders. How can we identify exogenous ligands mediating the effects of mGluRs? How do these ligands affect the receptor? The author Tobias Noeske presents the establishment of strategies for the identification and optimization of molecules acting as non-competitive anta gonists of group I mGluRs. These strategies ensure high diversity in the identi fied chemotypes not resembling original reference molecules ('scaffold-hop ping'). The detection of new scaffolds, in turn, is divided into two ap proa ches: First the development of pharmacological assays to screen com pounds at a certain target for their bioactivity, and second the evaluation of com pu ter aided methods for the identification of virtual hits to be screened on the pharmacological assays. Promising molecules were optimized regarding bio activity and selectivity, their binding mode investigated and, fi nally, com pared to existing lead compounds. This book addresses scientists in academia and industry working in early stage drug discovery, predominantly in computer aided drug design. Bücher > Fremdsprachige Bücher > Englische Bücher 220 x 150 x 12 mm , AV Akademikerverlag, Taschenbuch, AV Akademikerverlag<
Nr. A1023418722. Versandkosten:Lieferzeiten außerhalb der Schweiz 3 bis 21 Werktage, , Versandfertig innert 4 - 7 Werktagen, zzgl. Versandkosten. (EUR 18.67)
Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis ord… Mehr…
Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis orders. How can we identify exogenous ligands mediating the effects of mGluRs? How do these ligands affect the receptor? The author Tobias Noeske presents the establishment of strategies for the identification and optimization of molecules acting as non-competitive anta gonists of group I mGluRs. These strategies ensure high diversity in the identi fied chemotypes not resembling original reference molecules ('scaffold-hop ping'). The detection of new scaffolds, in turn, is divided into two ap proa ches: First the development of pharmacological assays to screen com pounds at a certain target for their bioactivity, and second the evaluation of com pu ter aided methods for the identification of virtual hits to be screened on the pharmacological assays. Promising molecules were optimized regarding bio activity and selectivity, their binding mode investigated and, fi nally, com pared to existing lead compounds. This book addresses scientists in academia and industry working in early stage drug discovery, predominantly in computer aided drug design. Buch (fremdspr.) Tobias Noeske Taschenbuch, AV Akademikerverlag, 22.05.2012, AV Akademikerverlag, 2012<
Nr. 32283116. Versandkosten:, Sofort lieferbar, DE. (EUR 0.00)
Noeske, Tobias: Ligand Binding in the Transmembrane Region: of Metabotropic Glutamate Receptors- Practical and Theoretical Investigations Paperback - Taschenbuch
1Da einige Plattformen keine Versandkonditionen übermitteln und diese vom Lieferland, dem Einkaufspreis, dem Gewicht und der Größe des Artikels, einer möglichen Mitgliedschaft der Plattform, einer direkten Lieferung durch die Plattform oder über einen Drittanbieter (Marketplace), etc. abhängig sein können, ist es möglich, dass die von eurobuch angegebenen Versandkosten nicht mit denen der anbietenden Plattform übereinstimmen.
Detailangaben zum Buch - Ligand Binding in the Transmembrane Region
EAN (ISBN-13): 9783639414929 ISBN (ISBN-10): 3639414926 Gebundene Ausgabe Taschenbuch Erscheinungsjahr: 2012 Herausgeber: AV Akademikerverlag Mai 2012
Buch in der Datenbank seit 2007-12-31T09:55:28+01:00 (Berlin) Detailseite zuletzt geändert am 2023-06-11T03:12:02+02:00 (Berlin) ISBN/EAN: 9783639414929
ISBN - alternative Schreibweisen: 3-639-41492-6, 978-3-639-41492-9 Alternative Schreibweisen und verwandte Suchbegriffe: Autor des Buches: noeske, tobias just
