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Lactoferrin and its Role in Wound Healing - Yoshiharu Takayama
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Yoshiharu Takayama:

Lactoferrin and its Role in Wound Healing - neues Buch

10, ISBN: 9789400724679

ID: 203179789400724679

Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers. Adult, Health & Well Being, Lactoferrin and its Role in Wound Healing~~ Yoshiharu Takayama~~Adult~~Health & Well Being~~9789400724679, en, Lactoferrin and its Role in Wound Healing, Yoshiharu Takayama, 9789400724679, Springer, 10/25/2011, , , , Springer, 10/25/2011

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Lactoferrin and its Role in Wound Healing - Takayama, Yoshiharu
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Takayama, Yoshiharu:

Lactoferrin and its Role in Wound Healing - neues Buch

2011, ISBN: 9400724675

ID: 9789400724679

In englischer Sprache. Verlag: Springer Netherland, Preface 1. Molecular regulation of wound healing - Introduction - The immediate response - Inflammatory response - Reepithelialization - Granulation tissue formation - Wound contraction - Angiogenesis - Remodeling - Resolution of inflammation - Proteases in wound healing - Anti-microbial peptides - Chronic wound healing - References 2. Role of hyaluronan in wound healing - Introduction - Structure - Biosynthesis - Mammalian hyaluronidase - Hyaluronan fragment - Role on cancer - Hyaluronan in dermis and epidermis - Role on wound healing - References 3. Lactoferrin structure, function and genetics - Introduction - Lactoferrin expression and localization - Lactoferrin structure - Iron-binding properties of lactoferrin - Lactoferrin metabolism - Anti-bacterial activity of lactoferrin - Bactericidal activity of lactoferrin derived peptides - Anti-viral activity of lactoferrin - Anti-parasitic and anti-fungal activity of lactoferrin - Immunoregulatory properties of lactoferrin - Anti-inflammatory activity of lactoferrin - Anti-oxidative effect of lactoferrin - Genetics - Other functions - References 4. Lactoferrin as a signaling mediator - Introduction - Intestinal lactoferrin receptor (Intelectin) - LDL receptor related protein (LRP) - Hepatocyte lactoferrin receptor - Nucleolin - Monocytes and macrophage lactoferrin receptor - Dendritic cell lactoferrin receptor - Lymphocyte lactoferrin receptor - Cell cycle control and apoptosis induction - Angiogenesis - Fibroblasts - Osteogenic differentiation - Osteoclasts - Chondrogenic differentiation - Adipogenesis - Lactoferrin receptor in brain capillary endothelial cells - Platelet lactoferrin receptor - Lactoferrin receptor in epithelial cells - Lactoferrin receptor in respiratory epithelial cells - Transcription regulator - References 5. Effects of lactoferrin on skin wound healing - Introduction - Cell proliferation and migration - Collagen gel contraction by fibroblasts - Molecular mechanism of wound healing - Regulation of cell adhesion - Hyaluronan synthesis - Production of extracellular matrix components - Corneal epithelia wound healing - Talactoferrin - Cutaneous immunity - Anti-apoptotic effect - Diabetic ulcers - References, PC-PDF, 108 Seiten, XII Seiten, 108 Seiten, [GR: 9692 - Nonbooks, PBS / Medizin/Nichtklinische Fächer], [SW: - Vorklinische Medizin, Grundlagenwissenschaften], [Ausgabe: 2012][PU:Springer Netherland]

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Lactoferrin and its Role in Wound Healing - Yoshiharu Takayama
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Yoshiharu Takayama:
Lactoferrin and its Role in Wound Healing - neues Buch

ISBN: 9789400724679

ID: 9789400724679

Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. Lactoferrin and its Role in Wound Healing: Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. Protein Science Receptors Wound Healing Reepithelialization Biomedical and Life Sciences Granulation tissue C Biomedicine general Cell Biology Lactoferrin Hyaluronan Membrane Biology Human Physiology, Springer Netherland

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Lactoferrin and its Role in Wound Healing - Takayama, Yoshiharu
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Takayama, Yoshiharu:
Lactoferrin and its Role in Wound Healing - neues Buch

2011, ISBN: 9400724675

ID: 9789400724679

In englischer Sprache. Verlag: Springer Netherland, PC-PDF, 107 Seiten, XI Seiten, 107 Seiten, 1., st Edition. [GR: 9692 - Nonbooks, PBS / Medizin/Nichtklinische Fächer], [SW: - Vorklinische Medizin, Grundlagenwissenschaften], [Ausgabe: 1][PU:Springer Netherland]

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Lactoferrin and its Role in Wound Healing - Yoshiharu Takayama
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2011, ISBN: 9789400724679

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Lactoferrin and its Role in Wound Healing
Autor:

Yoshiharu Takayama

Titel:

Lactoferrin and its Role in Wound Healing

ISBN-Nummer:

9789400724679

Detailangaben zum Buch - Lactoferrin and its Role in Wound Healing


EAN (ISBN-13): 9789400724679
ISBN (ISBN-10): 9400724675
Erscheinungsjahr: 2011
Herausgeber: Springer Netherland
107 Seiten
Sprache: eng/Englisch

Buch in der Datenbank seit 01.05.2012 10:20:21
Buch zuletzt gefunden am 16.11.2016 13:18:43
ISBN/EAN: 9789400724679

ISBN - alternative Schreibweisen:
94-007-2467-5, 978-94-007-2467-9

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