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The DNA Damage Response: Implications on Cancer Formation and Treatment - Kum Kum Khanna
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The DNA Damage Response: Implications on Cancer Formation and Treatment - gebunden oder broschiert

ISBN: 9789048125609

ID: 9789048125609

Implications on cancer formation and treatment The eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the `DNA damage response`. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci c damaging agents, immunode ciency, genomic instability, cancer predisposition and premature aging. The nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving eld, and the advances in our understanding of the complex network of processes that respond to DNA damage. The DNA Damage Response: Implications on Cancer Formation and Treatment: The eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the `DNA damage response`. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci c damaging agents, immunode ciency, genomic instability, cancer predisposition and premature aging. The nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving eld, and the advances in our understanding of the complex network of processes that respond to DNA damage. Krebs (Krankheit) / Therapie (diverse), Springer-Verlag Gmbh

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The DNA Damage Response
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The DNA Damage Response - neues Buch

ISBN: 9789048125609

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The? eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the "DNA damage response". This system operates in all. The? eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the "DNA damage response". This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The? nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving? eld, and the advances in our understanding of the complex network of processes that respond to DNA damage. Books, Medical~~Clinical & Internal Medicine~~Diseases & Disorders, The DNA Damage Response~~Book~~9789048125609, , , , , , , , , ,

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The DNA Damage Response: Implications on Cancer Formation and Treatment - Kum Kum Khanna
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The DNA Damage Response: Implications on Cancer Formation and Treatment - neues Buch

ISBN: 9789048125609

[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - The eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the 'DNA damage response'. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci c damaging agents, immunode ciency, genomic instability, cancer predisposition and premature aging. The nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving eld, and the advances in our understanding of the complex network of processes that respond to DNA damage., Neuware, gewerbliches Angebot, FixedPrice, [GW: 938g]

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The DNA Damage Response: Implications on Cancer Formation and Treatment - Kum Kum Khanna
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[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - The eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the 'DNA damage response'. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci c damaging agents, immunode ciency, genomic instability, cancer predisposition and premature aging. The nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving eld, and the advances in our understanding of the complex network of processes that respond to DNA damage. -, [SC: 0.00]

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The DNA Damage Response: Implications on Cancer Formation and Treatment Implications on cancer formation and treatment - Khanna, Kum Kum (Herausgeber); Shiloh, Yosef (Herausgeber)
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2010, ISBN: 904812560X

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Gebundene Ausgabe Krebs (Krankheit) / Therapie (diverse), mit Schutzumschlag, [PU:Springer-Verlag GmbH]

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The DNA Damage Response: Implications on Cancer Formation and Treatment
Autor:

Kum Kum Khanna

Titel:

The DNA Damage Response: Implications on Cancer Formation and Treatment

ISBN-Nummer:

9789048125609

The book The DNA Damage Response: Implications on Cancer Formation and Treatment brings together a great collection of review articles. The articles have been written by a group of experts who have a deep knowledge of the recent advances in the fields of DNA damage signalling and repair and their implications in carcinogenesis. The book is divided into chapters that deal with the elaborate surveillance system and repair mechanisms used by cells to suppress mutagenic lesions to avoid cancer. It provides snapshots of:* current understanding of DNA damage signalling, * cell cycle checkpoints, * some of the major DNA repair pathways, * functional links between DNA damage, * genomic instability and cancer, * implications of DNA damage for the development of new treatment modalities for cancer.

Detailangaben zum Buch - The DNA Damage Response: Implications on Cancer Formation and Treatment


EAN (ISBN-13): 9789048125609
ISBN (ISBN-10): 904812560X
Gebundene Ausgabe
Erscheinungsjahr: 2010
Herausgeber: Springer-Verlag GmbH
449 Seiten
Gewicht: 0,938 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 07.02.2007 16:41:40
Buch zuletzt gefunden am 04.10.2016 22:27:22
ISBN/EAN: 9789048125609

ISBN - alternative Schreibweisen:
90-481-2560-X, 978-90-481-2560-9

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