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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
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Guangtao Zhang:

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - signiertes Exemplar

ISBN: 3639309693

Taschenbuch, ID: 4296813010

[EAN: 9783639309690], [PU: VDM Verlag Dr. Mueller Akt.ges.&Co.KG], Brand NEW unread book. Soft cover bound book. We ship using Royal Mail or courier in the UK and Europe with tracking number for heavier or more valuable items. All USA orders have a parcel tracking number.Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 μM. It could serve as a promising drug to treat cholera. The second project is to use α-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Guangtao Zhang
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)

Guangtao Zhang:

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - signiertes Exemplar

ISBN: 3639309693

Taschenbuch, ID: 4296813010

[EAN: 9783639309690], [PU: VDM Verlag Dr. Mueller Akt.ges.&Co.KG], Brand NEW unread book. Soft cover bound book. We ship using Royal Mail or courier in the UK and Europe with tracking number for heavier or more valuable items. All USA orders have a parcel tracking number.Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 μM. It could serve as a promising drug to treat cholera. The second project is to use α-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Zhang, Guangtao
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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Taschenbuch

2011

ISBN: 9783639309690

ID: 2324501&WAN=10022&WBT=28664&WMID=W000000443

2011. / Pb ; KT ; Zhang:Design, Synthesis and Evaluation Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block Buch Taschenbuch

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Zhang, Guangtao
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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Taschenbuch

2011, ISBN: 9783639309690

ID: 2324501&WAN=10022&WBT=28664&WMID=W000000443

2011. / Pb ; KT ; Zhang:Design, Synthesis and Evaluation Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block Buch Taschenbuch

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Zhang, Guangtao
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Zhang, Guangtao:
Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR - Taschenbuch

2011, ISBN: 3639309693

Gebundene Ausgabe, ID: 10284024

Development of Bisubstrate Analog Inhibitors of Cholera Toxin and a-Helix Mimetics as Modulators of Dormancy Survival Regulator - Buch, gebundene Ausgabe, 160 S., Beilagen: Paperback, Erschienen: 2011 VDM Verlag, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR
Autor:

Zhang, Guangtao

Titel:

Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR

ISBN-Nummer:

9783639309690

Infectious diseases cause millions of deaths each year. The top single disease killers include tuberculosis and diarrheal diseases. The diarrheal diseases caused by cholera toxin and E. coli heat-labile enterotoxin constitute a large part of the diarrhea-related deaths worldwide each year. While there are some efficacious drugs against Vibrio cholerae in the market, their resistance is developing quickly. We wish to develop synthetic molecules that could bind to CT with a high affinity to block the enzymatic reaction catalyzed by CT. We designed, synthesized and evaluated bisubstrate analogs targeting the active site of CT. The most potent inhibitor demonstrated an IC50 of around 40 µM. It could serve as a promising drug to treat cholera. The second project is to use a-helix mimetics for probing the protein-protein interactions of DosR. The main function of DosR is to mediate the transition of Mycobacteria tuberculosis into dormancy and may contribute to latency. Disruption of the dimerization of DosR could keep MTB in an active state, so that the existing drugs could treat them effectively. We employed small molecules and peptides as tools to achieve the goal.

Detailangaben zum Buch - Design, Synthesis and Evaluation of Novel Inhibitors of CT and DosR


EAN (ISBN-13): 9783639309690
ISBN (ISBN-10): 3639309693
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2011

Buch in der Datenbank seit 01.07.2009 15:06:36
Buch zuletzt gefunden am 26.10.2015 22:58:59
ISBN/EAN: 9783639309690

ISBN - alternative Schreibweisen:
3-639-30969-3, 978-3-639-30969-0

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