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Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones - The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quinones
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Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones - The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quinones - Taschenbuch

2009, ISBN: 9783639076301

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Tuberculosis and Cancer are among the most devastating and therapeutically challenging diseases. The development of muti-drug resistance in TB causing bacteria, Mycobacterium tuberculosis and cancerous cells has prompted the search for effective novel compounds. This book focuses on the synthesis and the evaluation of different analogues of diospyrin, a proven anti-TB and anti-cancer agent. A number of novel binaphthoquinone and naphthoquinone-naphthalene biaryl compounds were synthesized by using Suzuki methodology. Several analogues were evaluated for their biological activity against fast growing bacteria viz., M. smegmatis and M. aurum and against a clinical strain of M. tuberculosis. Four novel quinones were also evaluated for their ability to induce apoptosis in three cancer cell lines viz., HeLa, MCF7, MG63 and one normal cell line i.e. CHO by using APOpercentage, DNA fragmentation and Cell cycle assays. This preliminary investigation could provoke an interest in scientific community to synthesize other structurally modified quinonoids in order to develop and establish them as potent drugs against mycobacterium and cancer., [SC: 0.00], Neuware, gewerbliches Angebot, 220 mm

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Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones - The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quinones
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Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones - The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quinones - Taschenbuch

2009, ISBN: 9783639076301

[ED: Taschenbuch / Paperback], [PU: VDM Verlag Dr. Müller], Tuberculosis and Cancer are among the most devastating and therapeutically challenging diseases. The development of muti-drug resistance in TB causing bacteria, Mycobacterium tuberculosis and cancerous cells has prompted the search for effective novel compounds. This book focuses on the synthesis and the evaluation of different analogues of diospyrin, a proven anti-TB and anti-cancer agent. A number of novel binaphthoquinone and naphthoquinone-naphthalene biaryl compounds were synthesized by using Suzuki methodology. Several analogues were evaluated for their biological activity against fast growing bacteria viz., M. smegmatis and M. aurum and against a clinical strain of M. tuberculosis. Four novel quinones were also evaluated for their ability to induce apoptosis in three cancer cell lines viz., HeLa, MCF7, MG63 and one normal cell line i.e. CHO by using APOpercentage, DNA fragmentation and Cell cycle assays. This preliminary investigation could provoke an interest in scientific community to synthesize other structurally modified quinonoids in order to develop and establish them as potent drugs against mycobacterium and cancer., Neuware, gewerbliches Angebot, 220 mm

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Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones - Sunil Sagar
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Sunil Sagar:
Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones - neues Buch

ISBN: 9783639076301

ID: 510ddf6426ec924cfbfed16f007de7f0

Tuberculosis and Cancer are among the most devastating and therapeutically challenging diseases. The development of muti-drug resistance in TB causing bacteria, Mycobacterium tuberculosis and cancerous cells has prompted the search for effective novel compounds. This book focuses on the synthesis and the evaluation of different analogues of diospyrin, a proven anti-TB and anti-cancer agent. A number of novel binaphthoquinone and naphthoquinone-naphthalene biaryl compounds were synthesized by using Suzuki methodology. Several analogues were evaluated for their biological activity against fast growing bacteria viz., M. smegmatis and M. aurum and against a clinical strain of M. tuberculosis. Four novel quinones were also evaluated for their ability to induce apoptosis in three cancer cell lines viz., HeLa, MCF7, MG63 and one normal cell line i.e. CHO by using APOpercentage, DNA fragmentation and Cell cycle assays. This preliminary investigation could provoke an interest in scientific community to synthesize other structurally modified quinonoids in order to develop and establish them as potent drugs against mycobacterium and cancer. Buch / Broschur, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Synthesis and Evaluation of anti-TB and Pro-apoptoticQuinones - Sagar, Sunil
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Sagar, Sunil:
Synthesis and Evaluation of anti-TB and Pro-apoptoticQuinones - Taschenbuch

2009, ISBN: 3639076303

Gebundene Ausgabe, ID: 5254012

The Synthesis and Evaluation of Potentialanti-Mycobacterium tuberculosis and Pro-apoptoticQuinones - Buch, gebundene Ausgabe, 120 S., Beilagen: Paperback, Erschienen: 2009 VDM Verlag, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones - Sunil Sagar
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Sunil Sagar:
Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones - neues Buch

ISBN: 9783639076301

ID: f52a13b289ec33d14cc737ec9bf278cc

Tuberculosis and Cancer are among the most, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Details zum Buch
Synthesis and Evaluation of anti-TB and Pro-apoptoticQuinones
Autor:

Sagar, Sunil

Titel:

Synthesis and Evaluation of anti-TB and Pro-apoptoticQuinones

ISBN-Nummer:

9783639076301

Detailangaben zum Buch - Synthesis and Evaluation of anti-TB and Pro-apoptoticQuinones


EAN (ISBN-13): 9783639076301
ISBN (ISBN-10): 3639076303
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2009
Herausgeber: VDM Verlag Dr. Müller

Buch in der Datenbank seit 01.04.2009 02:06:05
Buch zuletzt gefunden am 28.11.2016 18:17:36
ISBN/EAN: 9783639076301

ISBN - alternative Schreibweisen:
3-639-07630-3, 978-3-639-07630-1

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