Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a comple… Mehr…
Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases.; PDF; Scientific, Technical and Medical > Medicine: general issues > Medical equipment & techniques > Medi, Springer New York<
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Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a comple… Mehr…
Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field. Books > Biomedicine eBook, Springer Shop<
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(*) Derzeit vergriffen bedeutet, dass dieser Titel momentan auf keiner der angeschlossenen Plattform verfügbar ist.
This book explores the multifaceted regulatory interplay between integrin receptors and ion channels.The essays here explain how the extracellular matrix regulates processes as disparate … Mehr…
This book explores the multifaceted regulatory interplay between integrin receptors and ion channels.The essays here explain how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation. ; PDF \ Mihail Voicu; Scientific, Technical and Medical > Medicine: general issues > Medical equipment & techniques > Medi, Springer US<
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No. 9781441960665. Versandkosten:Instock, Despatched same working day before 3pm, zzgl. Versandkosten. Details...
(*) Derzeit vergriffen bedeutet, dass dieser Titel momentan auf keiner der angeschlossenen Plattform verfügbar ist.
Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a comple… Mehr…
Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases.; PDF; Scientific, Technical and Medical > Medicine: general issues > Medical equipment & techniques > Medi, Springer New York<
No. 9781441960665. Versandkosten:Instock, Despatched same working day before 3pm, zzgl. Versandkosten.
Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a comple… Mehr…
Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field. Books > Biomedicine eBook, Springer Shop<
This book explores the multifaceted regulatory interplay between integrin receptors and ion channels.The essays here explain how the extracellular matrix regulates processes as disparate … Mehr…
This book explores the multifaceted regulatory interplay between integrin receptors and ion channels.The essays here explain how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation. ; PDF \ Mihail Voicu; Scientific, Technical and Medical > Medicine: general issues > Medical equipment & techniques > Medi, Springer US<
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CD in der Datenbank seit 2011-05-22T17:32:09+02:00 (Berlin) Detailseite zuletzt geändert am 2023-04-03T15:56:47+02:00 (Berlin) EAN: 9781441960665
EAN - alternative Schreibweisen: 1-4419-6066-X, 978-1-4419-6066-5 Alternative Schreibweisen und verwandte Suchbegriffe: Titel der CD: ion
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Autor/in: Andrea Becchetti; Annarosa Arcangeli Titel: Advances in Experimental Medicine and Biology; Integrins and Ion Channels - Molecular Complexes and Signaling Verlag: Springer; Springer US; Landes Bioscience 124 Seiten Erscheinungsjahr: 2010-12-28 New York; NY; US Sprache: Englisch 149,79 € (DE) 154,00 € (AT) 177,00 CHF (CH) Available XX, 124 p. 23 illus.
EA; E107; eBook; Nonbooks, PBS / Medizin/Nichtklinische Fächer; Medizinische Forschung; Verstehen; activation; antibody; biology; cancer; cell; development; ion channels; membrane; migration; proliferation; protein; proteins; regulation; signal transduction; tissue; B; Biomedical Research; Biomedical and Life Sciences; BB
Integrin Structure and Functional Relation with Ion Channels.- to Ion Channels.- Biochemical Methods to Study the Interactions Between Integrins and Ion Channels.- Optical Methods in the Study of Protein-Protein Interactions.- Integrins and Signal Transduction.- Physical and Functional Interaction between Integrins and hERG1 Channels in Cancer Cells.- Coordinated Regulation of Vascular Ca2+ and K+ Channels by Integrin Signaling.- Adhesion-Dependent Modulation of Macrophage K+ Channels.- Integrin Receptors and Ligand-Gated Channels.- Integrins and Ion Channels in Cell Migration: Implications for Neuronal Development, Wound Healing and Metastatic Spread. Presents a series of essays on cellular models that have been studied Gives a brief historical background, summarizes the elements of integrin structure and outlines the main biological problems that involve signal transduction between the cell adhesion machinery and ion channels Provides a primer to the structure and physiology of the most relevant ion channel types Surveys recent views about intracellular signaling triggered by integrin activation, with special emphasis on tyrosine phosphorylation cascades and the relationship with growth factors and cytokines Reviews current technology for studying the molecular complexes formed by integral membrane proteins
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