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Mitochondrial Inhibitors and Neurodegenerative Disorders
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1999, ISBN: 089603805X, Lieferbar binnen 4-6 Wochen Versandkosten:Versandkostenfrei innerhalb der BRD

ID: 9780896038059

Internationaler Buchtitel. In englischer Sprache. Verlag: Springer-Verlag GmbH, HC runder Rücken kaschiert, 336 Seiten, L=235mm, B=155mm, H=25mm, Gew.=728gr, [GR: 16930 - HC/Allgemeinmedizin/Diagnostik/Therapie], Gebunden, Klappentext: Respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers -- many pioneers in the field -- detail the symptomology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The emphasis on 3-NP and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease demonstrate that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. The book also discusses recent therapeutic modalities aimed at rescuing the central nervous system from abnormal mitochondrial functioning. With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression. Respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers -- many pioneers in the field -- detail the symptomology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The emphasis on 3-NP and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease demonstrate that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. The book also discusses recent therapeutic modalities aimed at rescuing the central nervous system from abnormal mitochondrial functioning. With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression.

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Mitochondrial Inhibitors And Neurodegenerative Disorders
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ID: 6454368

Mitochondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function. The extraordinary dependence of cells on the energy provided by mito- chondrial oxidative metabolism of. Mitochondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function. The extraordinary dependence of cells on the energy provided by mito- chondrial oxidative metabolism of glucose, especially through critical organs such as the heart and brain, is underlined by the fatal consequences of toxins that interfere with the mitochondrial electron transport system. Consistent with their ancestry, the mitochondria have their own DNA that encodes many but not all of their proteins. The mitochon- dria and their genes come from the mother via the ovum since sperm do not possess mitochondria. This extranuclear form of inheritance derived exclusively from the female side has proven to be a powerful tool for tracing the evolution by the number of base substitutions in mtDNA. That mitochondrial gene mutations might be a source of human dis- ease became evident a decade ago with the characterization of a group of multisystem disorders, typically involving the nervous system, which are transmitted from mother to child. Specific point mutations in mtDNA have been associated with the different syndromes. Books, Medical~~Clinical & Internal Medicine~~Neurology & Clinical Neurophysiology, Mitochondrial Inhibitors And Neurodegenerative Disorders~~Book~~9780896038059~~C.V. Borlongan, H. Nishino, , , , , , , , , ,, [PU: Humana Press]

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Mitochondrial Inhibitors and Neurodegenerative Disorders - P Sanberg
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Hardback, [PU: Humana Press Inc.], This volume examines work on the utilization of mitochondrial inhibitors towards understanding the different mechanisms involved in neurodegenerative disorders., Neurology & Clinical Neurophysiology

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Mitochondrial Inhibitors and Neurodegenerative Disorders
Autor:

Paul R Sanberg

Titel:

Mitochondrial Inhibitors and Neurodegenerative Disorders

ISBN-Nummer:

9780896038059

Respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers -- many pioneers in the field -- detail the symptomology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The emphasis on 3-NP and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease demonstrate that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. The book also discusses recent therapeutic modalities aimed at rescuing the central nervous system from abnormal mitochondrial functioning. With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression.

Detailangaben zum Buch - Mitochondrial Inhibitors and Neurodegenerative Disorders


EAN (ISBN-13): 9780896038059
ISBN (ISBN-10): 089603805X
Gebundene Ausgabe
Erscheinungsjahr: 1999
Herausgeber: Springer-Verlag GmbH
336 Seiten
Gewicht: 0,728 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 12.10.2008 10:16:02
Buch zuletzt gefunden am 27.06.2016 10:06:43
ISBN/EAN: 9780896038059

ISBN - alternative Schreibweisen:
0-89603-805-X, 978-0-89603-805-9

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