ISBN: 9783847326410

[ED: Taschenbuch], [PU: LAP Lambert Academic Publishing], Neuware - Corneal transplantation is the oldest and most common form of solid organ transplantation. In uncomplicated first-time … Mehr…

[ED: Taschenbuch], [PU: LAP Lambert Academic Publishing], Neuware - Corneal transplantation is the oldest and most common form of solid organ transplantation. In uncomplicated first-time cases, corneal allografts enjoy a success rate of up to 90% even though the transplants are performed without HLA matching or the use of systemic immunosuppressive drugs. Yet, every year in the United States, nearly 8000 patients reject their transplanted corneas at a cost of a quarter of a billion dollars. In order to better understand the immune mechanisms underlying graft failure, my research examined the role of CD4+ Thelper lymphocytes in the process, notably the recently described Thelper 17 subset. Surprisingly, blockade of the effector CD4+ Thelper subsets, by depletion of their inflammatory cytokines, exacerbated corneal allograft rejection in a murine model of keratoplasty. Our investigations uncover novel protective roles for the cytokines IL-17A and IFN- , and describe how their interaction with T regulatory cells is required for anterior chamber associated immune deviation and corneal immune privilege., DE, [SC: 0.00], Neuware, gewerbliches Angebot, 220x150x9 mm, 156, [GW: 249g], PayPal, offene Rechnung, Banküberweisung, sofortueberweisung.de, Interntationaler Versand<

2011, ISBN: 3847326414

[EAN: 9783847326410], Neubuch, [PU: LAP Lambert Academic Publishing Dez 2011], This item is printed on demand - Print on Demand Neuware - Corneal transplantation is the oldest and most co… Mehr…

[EAN: 9783847326410], Neubuch, [PU: LAP Lambert Academic Publishing Dez 2011], This item is printed on demand - Print on Demand Neuware - Corneal transplantation is the oldest and most common form of solid organ transplantation. In uncomplicated first-time cases, corneal allografts enjoy a success rate of up to 90% even though the transplants are performed without HLA matching or the use of systemic immunosuppressive drugs. Yet, every year in the United States, nearly 8000 patients reject their transplanted corneas at a cost of a quarter of a billion dollars. In order to better understand the immune mechanisms underlying graft failure, my research examined the role of CD4+ Thelper lymphocytes in the process, notably the recently described Thelper 17 subset. Surprisingly, blockade of the effector CD4+ Thelper subsets, by depletion of their inflammatory cytokines, exacerbated corneal allograft rejection in a murine model of keratoplasty. Our investigations uncover novel protective roles for the cytokines IL-17A and IFN- , and describe how their interaction with T regulatory cells is required for anterior chamber associated immune deviation and corneal immune privilege. 156 pp. Englisch<

2011, ISBN: 9783847326410

LAP LAMBERT Academic Publishing, Taschenbuch, 156 Seiten, Publiziert: 2011-12-29T00:00:01Z, Produktgruppe: Buch, 0.53 kg, Medizin, Kategorien, Bücher, Ingenieurwissenschaft & Technik, Nat… Mehr…

LAP LAMBERT Academic Publishing, Taschenbuch, 156 Seiten, Publiziert: 2011-12-29T00:00:01Z, Produktgruppe: Buch, 0.53 kg, Medizin, Kategorien, Bücher, Ingenieurwissenschaft & Technik, Naturwissenschaften & Technik, Taschenbücher, Fremdsprachige Bücher, Englische Bücher, LAP LAMBERT Academic Publishing, 2011<

2011, ISBN: 9783847326410

Paperback, Nouveau livre, BRAND NEW BOOK! Shipped within 24-48 hours. Normal delivery time is 5-12 days. Please note some orders may be shipped from UK with same delivery timeframe, ***NO… Mehr…

Paperback, Nouveau livre, BRAND NEW BOOK! Shipped within 24-48 hours. Normal delivery time is 5-12 days. Please note some orders may be shipped from UK with same delivery timeframe, ***NO EXPEDITED ORDERS***, [PU: LAP LAMBERT Academic Publishing]<

2011, ISBN: 3847326414

[EAN: 9783847326410], Nouveau livre, [SC: 70.05], [PU: LAP LAMBERT Academic Publishing], Books