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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - Jalpeshkumar Bhavsar
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Jalpeshkumar Bhavsar:

Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - neues Buch

ISBN: 9783659137501

ID: 788df6458b773663d2cd33738003cc7d

Famotidine is histamine H2 receptor antagonist. It has bioavailability of 40 to 45% and it has shorter plasma half life of 2.5 to 3.5 hrs. The effective treatment of erosive esophagitis and Zolinger-Elisons syndrome requires administration of 20 mg of Famotidine 4 times a day. A conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations; thus a sustained release dosage form of famotidine is desirable. Direct access to the systemic circulation bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Moreover, the buccal route is easily accessible, has a good patient compliance and can be used in patients who can t swallow. Bilayer buccal tablet was prepared by using mucoadhesive polymer combination of Sodium CMC and Carbopol934P, by direct compression with backing layer of Ethyl cellulose. The optimized formulation F1 had given release of 102.57% in 8hrs and it had optimum swelling, mucoadhesive property and permeation from buccal mucosa. It also had desired drug release kinetics and found to be stable for the period of 1 month. Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Medizin / Pharmazie

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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - Jalpeshkumar Bhavsar
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
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Jalpeshkumar Bhavsar:

Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - neues Buch

ISBN: 9783659137501

ID: 78e5cc666bba5a855ee97e5572d728bd

Famotidine is histamine H2 receptor antagonist. It has bioavailability of 40 to 45% and it has shorter plasma half life of 2.5 to 3.5 hrs. The effective treatment of erosive esophagitis and Zolinger-Elisons syndrome requires administration of 20 mg of Famotidine 4 times a day. A conventional dose of 20 mg can inhibit gastric acid secretion up to 5 hours but not up to 10 hours. An alternative dose of 40 mg leads to plasma fluctuations; thus a sustained release dosage form of famotidine is desirable. Direct access to the systemic circulation bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Moreover, the buccal route is easily accessible, has a good patient compliance and can be used in patients who can t swallow. Bilayer buccal tablet was prepared by using mucoadhesive polymer combination of Sodium CMC and Carbopol934P, by direct compression with backing layer of Ethyl cellulose. The optimized formulation F1 had given release of 102.57% in 8hrs and it had optimum swelling, mucoadhesive property and permeation from buccal mucosa. It also had desired drug release kinetics and found to be stable for the period of 1 month. Buch / Broschur

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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - Bhavsar, Jalpeshkumar / Patel, Mukesh / Patel, Natvarlal
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Bhavsar, Jalpeshkumar / Patel, Mukesh / Patel, Natvarlal:
Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine - Taschenbuch

2012

ISBN: 3659137502

Gebundene Ausgabe, ID: 12263880

The formulation with deduction of acid secretion - Buch, gebundene Ausgabe, 132 S., Beilagen: Paperback, Erschienen: 2012 LAP Lambert Academic Publishing

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Formulation and in Vitro Evaluation of Buccal Tablet of Famotidine - Jalpeshkumar Bhavsar
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Jalpeshkumar Bhavsar:
Formulation and in Vitro Evaluation of Buccal Tablet of Famotidine - Taschenbuch

ISBN: 9783659137501

Paperback, [PU: LAP Lambert Academic Publishing], Pharmacology

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Formulation and in Vitro Evaluation of Buccal Tablet of Famotidine - NA
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Formulation and in Vitro Evaluation of Buccal Tablet of Famotidine - neues Buch

ISBN: 9783659137501

ID: 185573321

NA, Lambert Academic Publishing

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Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine
Autor:

Bhavsar, Jalpeshkumar / Patel, Mukesh / Patel, Natvarlal

Titel:

Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine

ISBN-Nummer:

3659137502

Detailangaben zum Buch - Formulation and In Vitro Evaluation of Buccal Tablet of Famotidine


EAN (ISBN-13): 9783659137501
ISBN (ISBN-10): 3659137502
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2012
Herausgeber: LAP Lambert Academic Publishing

Buch in der Datenbank seit 18.02.2009 14:22:14
Buch zuletzt gefunden am 29.09.2016 23:24:24
ISBN/EAN: 3659137502

ISBN - alternative Schreibweisen:
3-659-13750-2, 978-3-659-13750-1

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