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The Ubiquitin System In Health And Disease
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ISBN: 9783642098802

ID: 19231257

The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein-protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as. The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein-protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in?ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi?cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci?city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi?ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an?amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals. Books, Medical~~Medical General issues~~Medical Equipment & Techniques, The Ubiquitin System In Health And Disease~~Book~~9783642098802, , , , , , , , , ,, [PU: Springer, Berlin/Heidelberg/New York, NY]

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The Ubiquitin System in Health and Disease (Paperback)
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[EAN: 9783642098802], Neubuch, [PU: Springer-Verlag Berlin and Heidelberg GmbH Co. KG, Germany], Language: English Brand New Book ***** Print on Demand *****.The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein-protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in?ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi?cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci?city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi?ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an?-amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals.

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The Ubiquitin System in Health and Disease - Stefan Jentsch (Editor), Bernhard Haendler (Editor)
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ISBN: 9783642098802

ID: 9783642098802

Stefan Jentsch (Editor), Bernhard Haendler (Editor),Paperback - Softcover reprint of hardcover 1st ed. 2009, Edition: 1,Series: Ernst Schering Foundation Symposium Proceedings Series, English-language edition, Pub by Springer Berlin Heidelberg Textbooks New, Books~~Medicine~~Biochemistry, Ubiquitin-System-in-Health-and-Disease~~Stefan-Jentsch, 999999999, The Ubiquitin System in Health and Disease, Stefan Jentsch (Editor), Bernhard Haendler (Editor), 3642098800, Springer Berlin Heidelberg, , , , , Springer Berlin Heidelberg

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The Ubiquitin System in Health and Disease Ubiquitin-System-in-Health-and-Disease~~Stefan-Jentsch Medicine>Health Professions>Lab Medicine Paperback, Springer Berlin Heidelberg

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The Ubiquitin System in Health and Disease - Stefan Jentsch; Bernhard Haendler
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Softcover reprint of hardcover 1st ed. 2009, Softcover, Buch, [PU: Springer Berlin]

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The Ubiquitin System in Health and Disease
Autor:

Stefan Jentsch, Bernhard Haendler

Titel:

The Ubiquitin System in Health and Disease

ISBN-Nummer:

3642098800

The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. Most of the enzymes involved in adding or removing ubiquitin chains have been identified, but often their direct substrate and the type of ubiquitylation remains to be clarified. A better understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention and pave the way for improved therapies. The latest developments in this rapidly moving field are presented in this book.

Detailangaben zum Buch - The Ubiquitin System in Health and Disease


EAN (ISBN-13): 9783642098802
ISBN (ISBN-10): 3642098800
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: Springer-Verlag GmbH
208 Seiten
Gewicht: 0,241 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 17.09.2011 18:34:48
Buch zuletzt gefunden am 30.08.2016 02:10:29
ISBN/EAN: 3642098800

ISBN - alternative Schreibweisen:
3-642-09880-0, 978-3-642-09880-2

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