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Alpha-Gal specific humoral immune response to bioprostheses - Andreas Mangold
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Andreas Mangold:

Alpha-Gal specific humoral immune response to bioprostheses - neues Buch

ISBN: 9783639288377

ID: 3141731684237ad516e408f4dd250aa0

Biological heart valve implantation triggers the amplification of specific antibodies It has been shown that alpha-Gal is a relevant xenoantigen present on bioprostheses and elicits a specific IgM immune response. The aim of this work was to investigate whether that immune response proceeds after valve implantation. Plasma samples were collected from patients who underwent biovalve implantation or mechanical valve replacement, prior to, at ten days and at three months after cardiac surgery. ELISA was performed to quantify Gal specific antibodies. Three bioprosthetic tissue samples were obtained from patients who had to undergo reoperation within one week or one year after the initial operation. Presence of Gal epitopes and cell nuclei was determined. Alpha-Gal specific IgG was significantly increased three months after implantation of bioprostheses. In explanted bioprostheses one year after implantation, no Gal epitopes could be detected. These results indicate that the implantation of bioprostheses elicits a specific immune response against Gal bearing cells. The complete absence of Gal positive structures 12 months after implantation indicates a specific degradation of Gal bearing cells through previous exposure to the human blood circuit. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-639-28837-7, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Alpha-Gal specific humoral immune response to bioprostheses - Andreas Mangold
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
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Andreas Mangold:

Alpha-Gal specific humoral immune response to bioprostheses - neues Buch

ISBN: 9783639288377

ID: 4ef507f77d802305ff3239dae5a7523a

Biological heart valve implantation triggers the amplification of specific antibodies It has been shown that alpha-Gal is a relevant xenoantigen present on bioprostheses and elicits a specific IgM immune response. The aim of this work was to investigate whether that immune response proceeds after valve implantation. Plasma samples were collected from patients who underwent biovalve implantation or mechanical valve replacement, prior to, at ten days and at three months after cardiac surgery. ELISA was performed to quantify Gal specific antibodies. Three bioprosthetic tissue samples were obtained from patients who had to undergo reoperation within one week or one year after the initial operation. Presence of Gal epitopes and cell nuclei was determined. Alpha-Gal specific IgG was significantly increased three months after implantation of bioprostheses. In explanted bioprostheses one year after implantation, no Gal epitopes could be detected. These results indicate that the implantation of bioprostheses elicits a specific immune response against Gal bearing cells. The complete absence of Gal positive structures 12 months after implantation indicates a specific degradation of Gal bearing cells through previous exposure to the human blood circuit. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-639-28837-7, VDM

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Alpha-Gal specific humoral immune response to bioprostheses - Andreas Mangold
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Andreas Mangold:
Alpha-Gal specific humoral immune response to bioprostheses - neues Buch

ISBN: 9783639288377

ID: 58412118

It has been shown that alpha-Gal is a relevant xenoantigen present on bioprostheses and elicits a specific IgM immune response. The aim of this work was to investigate whether that immune response proceeds after valve implantation. Plasma samples were collected from patients who underwent biovalve implantation or mechanical valve replacement, prior to, at ten days and at three months after cardiac surgery. ELISA was performed to quantify Gal specific antibodies. Three bioprosthetic tissue samples were obtained from patients who had to undergo reoperation within one week or one year after the initial operation. Presence of Gal epitopes and cell nuclei was determined. Alpha-Gal specific IgG was significantly increased three months after implantation of bioprostheses. In explanted bioprostheses one year after implantation, no Gal epitopes could be detected. These results indicate that the implantation of bioprostheses elicits a specific immune response against Gal bearing cells. The complete absence of Gal positive structures 12 months after implantation indicates a specific degradation of Gal bearing cells through previous exposure to the human blood circuit. Biological heart valve implantation triggers the amplification of specific antibodies Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, VDM

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Alpha-Gal specific humoral immune response to bioprostheses - Andreas Mangold
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Andreas Mangold:
Alpha-Gal specific humoral immune response to bioprostheses - neues Buch

ISBN: 9783639288377

ID: 4be5844e1d3fae0659a43a9f9f1741ff

It has been shown that alpha-Gal is a relevant xenoantigen present on bioprostheses and elicits a specific IgM immune response. The aim of this work was to investigate whether that immune response proceeds after valve implantation. Plasma samples were collected from patients who underwent biovalve implantation or mechanical valve replacement, prior to, at ten days and at three months after cardiac surgery. ELISA was performed to quantify Gal specific antibodies. Three bioprosthetic tissue samples were obtained from patients who had to undergo reoperation within one week or one year after the initial operation. Presence of Gal epitopes and cell nuclei was determined. Alpha-Gal specific IgG was significantly increased three months after implantation of bioprostheses. In explanted bioprostheses one year after implantation, no Gal epitopes could be detected. These results indicate that the implantation of bioprostheses elicits a specific immune response against Gal bearing cells. The complete absence of Gal positive structures 12 months after implantation indicates a specific degradation of Gal bearing cells through previous exposure to the human blood circuit. Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Medizin / Klinische Fächer, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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Alpha-Gal specific humoral immune response to bioprostheses - Mangold, Andreas
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Mangold, Andreas:
Alpha-Gal specific humoral immune response to bioprostheses - Taschenbuch

2010, ISBN: 9783639288377

[ED: Softcover], [PU: Vdm Verlag Dr. Müller], It has been shown that alpha-Gal is a relevant xenoantigen present on bioprostheses and elicits a specific IgM immune response. The aim of this work was to investigate whether that immune response proceeds after valve implantation. Plasma samples were collected from patients who underwent biovalve implantation or mechanical valve replacement, prior to, at ten days and at three months after cardiac surgery. ELISA was performed to quantify Gal specific antibodies. Three bioprosthetic tissue samples were obtained from patients who had to undergo reoperation within one week or one year after the initial operation. Presence of Gal epitopes and cell nuclei was determined. Alpha-Gal specific IgG was significantly increased three months after implantation of bioprostheses. In explanted bioprostheses one year after implantation, no Gal epitopes could be detected. These results indicate that the implantation of bioprostheses elicits a specific immune response against Gal bearing cells. The complete absence of Gal positive structures 12 months after implantation indicates a specific degradation of Gal bearing cells through previous exposure to the human blood circuit. 2010. 84 S. Versandfertig in 3-5 Tagen, [SC: 0.00], Neuware, gewerbliches Angebot

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Alpha-Gal specific humoral immune response to bioprostheses: Biological heart valve implantation triggers the amplification of specific antibodies
Autor:

Mangold, Andreas

Titel:

Alpha-Gal specific humoral immune response to bioprostheses: Biological heart valve implantation triggers the amplification of specific antibodies

ISBN-Nummer:

3639288378

It has been shown that alpha-Gal is a relevant xenoantigen present on bioprostheses and elicits a specific IgM immune response. The aim of this work was to investigate whether that immune response proceeds after valve implantation. Plasma samples were collected from patients who underwent biovalve implantation or mechanical valve replacement, prior to, at ten days and at three months after cardiac surgery. ELISA was performed to quantify Gal specific antibodies. Three bioprosthetic tissue samples were obtained from patients who had to undergo reoperation within one week or one year after the initial operation. Presence of Gal epitopes and cell nuclei was determined. Alpha-Gal specific IgG was significantly increased three months after implantation of bioprostheses. In explanted bioprostheses one year after implantation, no Gal epitopes could be detected. These results indicate that the implantation of bioprostheses elicits a specific immune response against Gal bearing cells. The complete absence of Gal positive structures 12 months after implantation indicates a specific degradation of Gal bearing cells through previous exposure to the human blood circuit.

Detailangaben zum Buch - Alpha-Gal specific humoral immune response to bioprostheses: Biological heart valve implantation triggers the amplification of specific antibodies


EAN (ISBN-13): 9783639288377
ISBN (ISBN-10): 3639288378
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: VDM Verlag

Buch in der Datenbank seit 14.07.2007 16:59:59
Buch zuletzt gefunden am 01.11.2016 18:15:04
ISBN/EAN: 3639288378

ISBN - alternative Schreibweisen:
3-639-28837-8, 978-3-639-28837-7

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