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Molecular Mechanisms Of Nitroglycerin Bioactivation - Matteo Beretta
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ISBN: 9783639063325

ID: a67cedb73ed55330d22ebd66d96b0f28

New findings about GTN-derived nitric oxide formation Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite; (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols; (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance; (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity; (v) GTN reduction to NO also by cytosolic ALDH1; (vi) non-enzymatic GTN bioactivation by ascorbate; (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-639-06332-5, VDM Verlag

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Molecular Mechanisms Of Nitroglycerin Bioactivation - Matteo Beretta
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Molecular Mechanisms Of Nitroglycerin Bioactivation - neues Buch

ISBN: 9783639063325

ID: 179685679

Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite; (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols; (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance; (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity; (v) GTN reduction to NO also by cytosolic ALDH1; (vi) non-enzymatic GTN bioactivation by ascorbate; (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation. New findings about GTN-derived nitric oxide formation Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, VDM Verlag

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Beretta, Matteo
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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Taschenbuch

2010

ISBN: 9783639063325

[ED: Softcover], [PU: Vdm Verlag Dr. Müller], Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity (v) GTN reduction to NO also by cytosolic ALDH1 (vi) non-enzymatic GTN bioactivation by ascorbate (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation.2010. 200 S.Versandfertig in 3-5 Tagen, [SC: 0.00]

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Beretta, Matteo
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Beretta, Matteo:
MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Taschenbuch

2010, ISBN: 9783639063325

[ED: Softcover], [PU: Vdm Verlag Dr. Müller], Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity (v) GTN reduction to NO also by cytosolic ALDH1 (vi) non-enzymatic GTN bioactivation by ascorbate (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation.2010. 200 S.Versandfertig in 3-5 Tagen

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Beretta, Matteo
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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION - Taschenbuch

2010, ISBN: 3639063325

ID: 13788052820

[EAN: 9783639063325], Neubuch, This item is printed on demand for shipment within 3 working days., [PU: VDM Verlag Dr. Müller, Saarbrücken]

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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION: New findings about GTN-derived nitric oxide formation
Autor:

Beretta, Matteo

Titel:

MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION: New findings about GTN-derived nitric oxide formation

ISBN-Nummer:

3639063325

Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive. This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite; (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols; (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance; (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity; (v) GTN reduction to NO also by cytosolic ALDH1; (vi) non-enzymatic GTN bioactivation by ascorbate; (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation.

Detailangaben zum Buch - MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION: New findings about GTN-derived nitric oxide formation


EAN (ISBN-13): 9783639063325
ISBN (ISBN-10): 3639063325
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: VDM Verlag
200 Seiten
Gewicht: 0,314 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 19.08.2008 19:23:41
Buch zuletzt gefunden am 08.01.2016 00:56:04
ISBN/EAN: 3639063325

ISBN - alternative Schreibweisen:
3-639-06332-5, 978-3-639-06332-5

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