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The Physiological and Pathophysiological Roles of Melanotransferrin - Suryo Rahmanto, Yohan; Des Richardson, and
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Suryo Rahmanto, Yohan; Des Richardson, and:

The Physiological and Pathophysiological Roles of Melanotransferrin - Taschenbuch

2008, ISBN: 3639046005, Lieferbar binnen 4-6 Wochen

ID: 9783639046007

Internationaler Buchtitel. In englischer Sprache. Verlag: VDM Verlag, Paperback, 220 Seiten, L=220mm, B=150mm, H=13mm, Gew.=344gr, [GR: 16790 - HC/Biologie/Sonstiges], Kartoniert/Broschiert, Klappentext: Melanotransferrin is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosyl phosphatidylinositol anchor. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport. Therefore, it was important to investigate the function of this molecule in order to clarify its role in biology. To define the roles of MTf, six models were developed during this investigation. These included: MTf knockout mouse; down-regulation of MTf expression in SK-Mel-28 and SK-Mel-2 melanoma cells; hyper-expression of MTf in SK-N-MC neuroepithelioma and LMTK fibroblasts cells; and a MTf transgenic mouse with MTf hyper-expression. These investigations clearly demonstrate no essential role for MTf in Fe metabolism both in vitro and in vivo. In addition, this study generates novel in vitro and in vivo models for further investigating MTf function. Significantly, the work presented has identified novel role(s) for MTf in cell proliferation, migration and melanoma tumourigenesis.

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The Physiological and Pathophysiological Roles of Melanotransferrin - Suryo Rahmanto, Yohan; Des Richardson, and
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Suryo Rahmanto, Yohan; Des Richardson, and:

The Physiological and Pathophysiological Roles of Melanotransferrin - Taschenbuch

2008, ISBN: 3639046005, Lieferbar binnen 4-6 Wochen

ID: 9783639046007

Internationaler Buchtitel. In englischer Sprache. Verlag: VDM Verlag, Paperback, 220 Seiten, L=220mm, B=150mm, H=13mm, Gew.=344gr, [GR: 16790 - HC/Biologie/Sonstiges], Kartoniert/Broschiert, Klappentext: Melanotransferrin is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosyl phosphatidylinositol anchor. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport. Therefore, it was important to investigate the function of this molecule in order to clarify its role in biology. To define the roles of MTf, six models were developed during this investigation. These included: MTf knockout mouse; down-regulation of MTf expression in SK-Mel-28 and SK-Mel-2 melanoma cells; hyper-expression of MTf in SK-N-MC neuroepithelioma and LMTK fibroblasts cells; and a MTf transgenic mouse with MTf hyper-expression. These investigations clearly demonstrate no essential role for MTf in Fe metabolism both in vitro and in vivo. In addition, this study generates novel in vitro and in vivo models for further investigating MTf function. Significantly, the work presented has identified novel role(s) for MTf in cell proliferation, migration and melanoma tumourigenesis.

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The Physiological and Pathophysiological Roles of Melanotransferrin - Yohan Suryo Rahmanto
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ISBN: 9783639046007

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Melanotransferrin is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosyl phosphatidylinositol anchor. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport. Therefore, it was important to investigate the function of this molecule in order to clarify its role in biology. To define the roles of MTf, six models were developed during this investigation. These included: MTf knockout mouse; down-regulation of MTf expression in SK-Mel-28 and SK-Mel-2 melanoma cells; hyper-expression of MTf in SK-N-MC neuroepithelioma and LMTK fibroblasts cells; and a MTf transgenic mouse with MTf hyper-expression. These investigations clearly demonstrate no essential role for MTf in Fe metabolism both in vitro and in vivo. In addition, this study generates novel in vitro and in vivo models for further investigating MTf function. Significantly, the work presented has identified novel role(s) for MTf in cell proliferation, migration and melanoma tumourigenesis. Bücher / Naturwissenschaften, Medizin, Informatik & Technik / Biologie, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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The Physiological and Pathophysiological Roles of Melanotransferrin - Suryo Rahmanto, Yohan
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Suryo Rahmanto, Yohan:
The Physiological and Pathophysiological Roles of Melanotransferrin - Taschenbuch

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2008. ; KT ; Suryo Rahmanto:The Physiological and Pa Melanotransferrin is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosyl phosphatidylinositol anchor. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport. Therefore, it was important to investigate the function of this molecule in order to clarify its role in biology. To define the roles of MTf, six models were developed during this investigation. These included: MTf knockout mouse; down-regulation of MTf expression in SK-Mel-28 and SK-Mel-2 melanoma cells; hyper-expression of MTf in SK-N-MC neuroepithelioma and LMTK fibroblasts cells; and a MTf transgenic mouse with MTf hyper-expression. These investigations clearly demonstrate no essential role for MTf in Fe metabolism both in vitro and in vivo. In addition, this study generates n ovel in vitro and in vivo models for further investigating MTf function. Significantly, the work presented has identified novel role(s) for MTf in cell proliferation, migration and melanoma tumourigenesis. Buch Taschenbuch

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The Physiological and Pathophysiological Roles of Melanotransferrin - Suryo Rahmanto, Yohan / Des Richardson, and
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Suryo Rahmanto, Yohan / Des Richardson, and:
The Physiological and Pathophysiological Roles of Melanotransferrin - Taschenbuch

2008, ISBN: 3639046005

Gebundene Ausgabe, ID: 4763885

Role of Melanotransferrin in Cell Proliferation, Migration and Melanoma Tumourigenesis - Buch, gebundene Ausgabe, 216 S., Beilagen: Paperback, Erschienen: 2008 VDM Verlag, [PU: VDM Verlag Dr. Müller, Saarbrücken]

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The Physiological and Pathophysiological Roles of Melanotransferrin
Autor:

Suryo Rahmanto, Yohan; Des Richardson, and

Titel:

The Physiological and Pathophysiological Roles of Melanotransferrin

ISBN-Nummer:

3639046005

Melanotransferrin is a transferrin homologue that is found predominantly bound to the cell membrane via a glycosyl phosphatidylinositol anchor. Melanotransferrin was originally identified at high levels in melanoma cells and other tumours, but at lower levels in normal tissues. Since its discovery, the function of MTf has remained intriguing, particularly regarding its role in cancer cell iron transport. Therefore, it was important to investigate the function of this molecule in order to clarify its role in biology. To define the roles of MTf, six models were developed during this investigation. These included: MTf knockout mouse; down-regulation of MTf expression in SK-Mel-28 and SK-Mel-2 melanoma cells; hyper-expression of MTf in SK-N-MC neuroepithelioma and LMTK fibroblasts cells; and a MTf transgenic mouse with MTf hyper-expression. These investigations clearly demonstrate no essential role for MTf in Fe metabolism both in vitro and in vivo. In addition, this study generates novel in vitro and in vivo models for further investigating MTf function. Significantly, the work presented has identified novel role(s) for MTf in cell proliferation, migration and melanoma tumourigenesis.

Detailangaben zum Buch - The Physiological and Pathophysiological Roles of Melanotransferrin


EAN (ISBN-13): 9783639046007
ISBN (ISBN-10): 3639046005
Gebundene Ausgabe
Taschenbuch
Erscheinungsjahr: 2008
Herausgeber: VDM Verlag
220 Seiten
Gewicht: 0,344 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 06.10.2008 18:02:23
Buch zuletzt gefunden am 22.10.2016 07:45:03
ISBN/EAN: 3639046005

ISBN - alternative Schreibweisen:
3-639-04600-5, 978-3-639-04600-7

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