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The Ubiquitin System in Health and Disease - S. Jentsch#B. Haendler
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The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in?ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi?cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci?city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi?ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an?-amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals. The Ubiquitin System in Health and Disease Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, Springer

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The Ubiquitin System in Health and Disease - Stefan Jentsch
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[ED: Buch], [PU: Springer-Verlag GmbH], Neuware - The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein-protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in ammation, central nervous system disorders, and metabolic dysfunction. Ubiquitin is a highly conserved 76-amino acid protein which is transferred to its target protein in an ATP-dependent manner. This post-translational modi cation takes place in a hierarchical, three-step fashion involving an E1 ubiquitin-activating enzyme, an E2 ubiquit- conjugating enzyme, and an E3 ubiquitin ligase. Substrate speci city is predominantly controlled by members of a large family of E3 - zymes, which form complexes with the proteins that will be modi ed. This ultimately leads to the covalent attachment of the C-terminus of ubiquitin to usually an -amino group of a lysine residue in the targeted protein. Additional ubiquitin transfer to lysine-48 of ubiquitin itself will form a polyubiquitin chain, which usually targets the conjugate for degradation by the proteasome. By contrast, mono- or polyubiquityla- VI Preface tion involving lysine-63 is normally involved in the control of protein activity. Ubiquitylation can be reverted by deubiquitylating enzymes, of which approximately 95 exist in mammals., Neuware, gewerbliches Angebot, FixedPrice, [GW: 391g]

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The Ubiquitin System in Health and Disease
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The Ubiquitin System in Health and Disease - neues Buch

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The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. Most of the enzymes involved in adding or removing ubiquitin chains have been identified, but often their direct substrate and the type of ubiquitylation remains to be clarified. A better understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention and pave the way for improved therapies. The latest developments in this rapidly moving field are presented in this book. Books, Health and Well Being, The Ubiquitin System in Health and Disease Books>Health and Well Being, Springer Berlin Heidelberg

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The Ubiquitin System in Health and Disease - Jentsch, Stefan / Haendler, Bernhard
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The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. Most of the enzymes involved in adding or removing ubiquitin chains have been identified, but often their direct substrate and the type of ubiquitylation remains to be clarified. A better understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention and pave the way for improved therapies. The latest developments in this rapidly moving field are presented in this book. The Ubiquitin System in Health and Disease Jentsch, Stefan / Haendler, Bernhard, Springer

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Jentsch, Stefan (Herausgeber); Haendler, B. (Herausgeber):
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2008, ISBN: 3540851062

ID: A6169661

Gebundene Ausgabe Biochemie (Heilmethode), Biomedizin, Medizin / Biomedizin, Gesundheitswesen, mit Schutzumschlag neu, [PU:Springer-Verlag GmbH]

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The Ubiquitin System in Health and Disease
Autor:

Stefan Jentsch

Titel:

The Ubiquitin System in Health and Disease

ISBN-Nummer:

3540851062

The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. Most of the enzymes involved in adding or removing ubiquitin chains have been identified, but often their direct substrate and the type of ubiquitylation remains to be clarified. A better understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention and pave the way for improved therapies. The latest developments in this rapidly moving field are presented in this book.

Detailangaben zum Buch - The Ubiquitin System in Health and Disease


EAN (ISBN-13): 9783540851066
ISBN (ISBN-10): 3540851062
Gebundene Ausgabe
Erscheinungsjahr: 2008
Herausgeber: Springer-Verlag GmbH
191 Seiten
Gewicht: 0,391 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 17.05.2007 11:51:04
Buch zuletzt gefunden am 22.10.2016 07:40:37
ISBN/EAN: 3540851062

ISBN - alternative Schreibweisen:
3-540-85106-2, 978-3-540-85106-6

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