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Bioisosteres in Medicinal Chemistry - Wiley-VCH
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Bioisosteres in Medicinal Chemistry - neues Buch

2012, ISBN: 9783527330157

ID: 220159903

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section. Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. Bücher > Fremdsprachige Bücher > Englische Bücher gebundene Ausgabe 22.08.2012, Wiley-VCH, .201

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Bioisosteres in Medicinal Chemistry - Wiley-VCH
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Wiley-VCH:

Bioisosteres in Medicinal Chemistry - neues Buch

ISBN: 9783527330157

ID: 85543084b244e4e849653084fcb99817

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section. Bücher / Fremdsprachige Bücher / Englische Bücher 978-3-527-33015-7, Wiley-VCH

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Bioisosteres in Medicinal Chemistry - Wiley-VCH
Vergriffenes Buch, derzeit bei uns nicht verfügbar.
(*)
Wiley-VCH:
Bioisosteres in Medicinal Chemistry - neues Buch

ISBN: 9783527330157

ID: 697930064

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section. Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, Wiley-VCH

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Bioisosteres in Medicinal Chemistry, Volume 54 - Wiley-VCH
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Bioisosteres in Medicinal Chemistry, Volume 54 - gebunden oder broschiert

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Bioisosteres in Medicinal Chemistry - Brown, Nathan (Herausgeber)
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Bioisosteres in Medicinal Chemistry - gebunden oder broschiert

2012, ISBN: 3527330151

ID: A19162103

Gebundene Ausgabe Chemie / Medizin, mit Schutzumschlag neu, [PU:Wiley VCH Verlag GmbH]

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Details zum Buch
Bioisosteres in Medicinal Chemistry
Autor:

Nathan Brown

Titel:

Bioisosteres in Medicinal Chemistry

ISBN-Nummer:

3527330151

Detailangaben zum Buch - Bioisosteres in Medicinal Chemistry


EAN (ISBN-13): 9783527330157
ISBN (ISBN-10): 3527330151
Gebundene Ausgabe
Erscheinungsjahr: 2012
Herausgeber: Wiley VCH Verlag GmbH
237 Seiten
Gewicht: 0,638 kg
Sprache: Englisch

Buch in der Datenbank seit 08.03.2008 07:09:28
Buch zuletzt gefunden am 05.01.2017 06:04:21
ISBN/EAN: 3527330151

ISBN - alternative Schreibweisen:
3-527-33015-1, 978-3-527-33015-7

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