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Optimization in Drug Discovery
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ISBN: 9781617374999

Although parallel synthesis combined with high-throughput screening has made it easier to generate highly potent drug candidates, many of these compounds never make the grade because they either prove to be unsafe or lack the necessary physicochemical and pharmacokinetic properties. In Optimization in Drug Discovery: In Vitro Methods, a panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world provide proven solutions to this expensive problem with a collection of cutting-edge experimental prools for early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. All prools follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Optimization in Drug Discovery: In Vitro Methods systematically collects and describes the key methods for uncovering-as early in the discovery stage as possible-those defects that can eliminate candidate drugs from preclinical and clinical development. Textbooks New Books ~~ Medicine~~ Pharmacology Optimization-in-Drug-Discovery~~Zhengyin-Yan Springer-Verlag New York, LLC A panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort.

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2010, ISBN: 1617374997, Lieferbar binnen 4-6 Wochen Versandkosten:Versandkostenfrei innerhalb der BRD

ID: 9781617374999

Internationaler Buchtitel. In englischer Sprache. Verlag: SPRINGER VERLAG GMBH, 436 Seiten, L=152mm, B=229mm, H=25mm, Gew.=635gr, Softcover of Or. [GR: 26920 - TB/Medizin/Allgemeines, Lexika], [SW: - Medical / Nursing], Kartoniert/Broschiert, Klappentext: A panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort. A panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort.

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Optimization in Drug Discovery Reprint - Gary W. Caldwell, Zhengyin Yan
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Optimization in Drug Discovery Reprint Author :Gary W. Caldwell, Zhengyin Yan 9781617374999 1617374997

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2010, ISBN: 9781617374999

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1st ed. Softcover of orig. ed. 2004, Softcover, Buch, [PU: Humana Press Inc.]

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Optimization in Drug Discovery
Autor:

Gary W. Caldwell, Zhengyin Yan

Titel:

Optimization in Drug Discovery

ISBN-Nummer:

1617374997

A panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort.

Detailangaben zum Buch - Optimization in Drug Discovery


EAN (ISBN-13): 9781617374999
ISBN (ISBN-10): 1617374997
Taschenbuch
Erscheinungsjahr: 2010
Herausgeber: SPRINGER VERLAG GMBH
436 Seiten
Gewicht: 0,635 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 11.06.2012 03:57:57
Buch zuletzt gefunden am 26.10.2016 14:55:55
ISBN/EAN: 1617374997

ISBN - alternative Schreibweisen:
1-61737-499-7, 978-1-61737-499-9

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