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Killer Lymphocytes - Gideon Berke#William R. Clark
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ISBN: 9781402032691

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Killer Lymphocytes The existence of a unique kind of immune cell the killer lymphocyt- which destroys other cells in a highly specific manner, has fascinated immunologists for almost half a century. How do these cells, whose precursors have lived in communal harmony with their host, decide that some of their cohabitants must die? And how do they kill them? The definition of killer lymphocytes came from discovery of their roles in a wide range of in vivo phenomena such as transplant rejection, virus infection and its related immunopathologies, and anti-tumor responses. Yet for the most part almost everything we know about these cells has come from studying them in vitro. They have yielded their secrets slowly and reluctantly. To understand fully how they work, geneticists and immunologists had to unravel the major histocompatibility systems of vertebrates, a long and torturous road that provided some of the darkest hours of immunology. The search for antigen-sensing receptors on both T cells and NK cells was scarcely less frustrating. And the holy grail of ce- mediated cytotoxicity defining the mechanism by which killer cells take down their adversaries sorely tested the ingenuity, patience and mutual good will of laboratories around the world. These questions have now largely been answered. But do we really understand these cells? We can tame them to a large degree in transplant rejection. It may yet turn out that we can harness their immunotherapeutic potential in treating viral and malignant disease. Bücher / Fremdsprachige Bücher / Englische Bücher 978-1-4020-3269-1, Springer

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Killer Lymphocytes - Gideon Berke#William R. Clark
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Gideon Berke#William R. Clark:

Killer Lymphocytes - neues Buch

ISBN: 9781402032691

ID: 226271882

The existence of a unique kind of immune cell the killer lymphocyt- which destroys other cells in a highly specific manner, has fascinated immunologists for almost half a century. How do these cells, whose precursors have lived in communal harmony with their host, decide that some of their cohabitants must die? And how do they kill them? The definition of killer lymphocytes came from discovery of their roles in a wide range of in vivo phenomena such as transplant rejection, virus infection and its related immunopathologies, and anti-tumor responses. Yet for the most part almost everything we know about these cells has come from studying them in vitro. They have yielded their secrets slowly and reluctantly. To understand fully how they work, geneticists and immunologists had to unravel the major histocompatibility systems of vertebrates, a long and torturous road that provided some of the darkest hours of immunology. The search for antigen-sensing receptors on both T cells and NK cells was scarcely less frustrating. And the holy grail of ce- mediated cytotoxicity defining the mechanism by which killer cells take down their adversaries sorely tested the ingenuity, patience and mutual good will of laboratories around the world. These questions have now largely been answered. But do we really understand these cells? We can tame them to a large degree in transplant rejection. It may yet turn out that we can harness their immunotherapeutic potential in treating viral and malignant disease. Killer Lymphocytes Buch (fremdspr.) Bücher>Fremdsprachige Bücher>Englische Bücher, Springer

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Killer Lymphocytes - Berke, Gideon; Clark, William R.
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ISBN: 9781402032691

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Advanced analysis of the field of cell-mediated cytotoxicity, including a comprehensive examination of key papers underlying its evolution Thorough discussion of the most recent advances in the field Contains appropriate background information on immunological topics necessary to understand and use the book Science Science eBook, Springer Netherlands

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Killer Lymphocytes 1st Edition - Gideon Berke
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ISBN: 9781402032691

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Killer Lymphocytes 1st Edition Author :Gideon Berke 9781402032691 1402032692, [PU: Springer]

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Killer Lymphocytes
Autor:

Berke, Gideon; Clark, William R.

Titel:

Killer Lymphocytes

ISBN-Nummer:

1402032692

We have known about the existence of killer lymphocytes since 1960, when they were discovered in connection with transplant rejection in vivo. Since then we have uncovered at least five subsets of lymphocytes that can kill other cells in vitro, establishing the study of cell-mediated cytotoxicity (CMC) as a major field of immunological inquiry. Berke and Clark summarize the extensive literature based on the study of CMC in vitro. Several important questions about killer cells have now been answered, for example, how they go about destroying other cells. Research ultimately revealed at least three lytic mechanisms available to killer lymphocytes. But do killer cells actually use these mechanisms in vivo? The possible involvement of CMC in transplant rejection, control of intracellular parasites, cancer, autoimmunity, and immune homeostatic regulation is analyzed in detail, yielding some surprising findings, and outlining important questions that remain unanswered. This extensively documented, comprehensive survey of cell-mediated cytotoxicity traces the history of killer lymphocytes from 1960 to the present, providing a definitive resource for specialists and non-specialists alike. TOC:Basic Immunobiology: A Primer.- Cytotoxic T Lymphocytes: Generation and Cellular Properties.- Cytotoxic T Lymphocytes: Target Cell Recognition and Binding.- Cytotoxic T Lymphocytes: Target Cell Killing: Cellular Parameters.- Cytotoxic T Lymphocytes: Target Cell Killing: Molecular Mechanisms.- Innate Cell-mediated Immunity.- The Role of Cytotoxicity in Allograft Rejection In Vivo.- Cytotoxicity in Immune Defenses Against Intracellular Parasites.- Killer Cells and Cancer.- Autoimmunity.- Homeostasis, Memory and CTL Vaccines.

Detailangaben zum Buch - Killer Lymphocytes


EAN (ISBN-13): 9781402032691
ISBN (ISBN-10): 1402032692
Gebundene Ausgabe
Erscheinungsjahr: 2005
Herausgeber: SPRINGER VERLAG GMBH
364 Seiten
Gewicht: 0,785 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 25.05.2007 06:24:17
Buch zuletzt gefunden am 16.10.2016 17:43:20
ISBN/EAN: 1402032692

ISBN - alternative Schreibweisen:
1-4020-3269-2, 978-1-4020-3269-1

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