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G Protein-Coupled Receptors: Molecular Pharmacology from Academic Concept to Pharmaceutical Research - Vauquelin, Georges / Mentzer, Bengt Von
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Vauquelin, Georges / Mentzer, Bengt Von:

G Protein-Coupled Receptors: Molecular Pharmacology from Academic Concept to Pharmaceutical Research - gebrauchtes Buch

ISBN: 9780470516478

ID: 1525989

G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly. "G Protein-coupled Receptors: Molecular Pharmacology" provides a clear summary of the current knowledge in this fast-evolving field. The book sets out with an introduction to signalling molecules and their receptors, and an overview of the technical approaches used to investigate these interactions. Structural, functional and especially pharmacological aspects of GPCRs are then discussed in more detail and much attention is devoted to the analysis and interpretation of experimental data. The now widespread use of recombinant cell lies, receptor mutants and related artifices in drug research is critically evaluated. Special attention is also devoted to topical but often poorly understood concepts, such as insurmountable antagonism, inverse agonism and allosteric interactions. By combining general information with the major state-of-the-art concepts in GPCR-research, this outstanding book equips the reader with the necessary background for understanding and critically evaluating the current literature. Written by two experts from academia and industry, "G Protein-coupled Receptors: Molecular Pharmacology" offers a unique view of academic and applied approaches aiming to reveal new ideas in pharmaceutical research. The book is of interest to anyone involved in drug development and preclinical research and those who need to function within multi-disciplinary teams in the pharmaceutical industry: from investigators to product managers or clinicians who seek to have a broad mechanistic understanding of drug-receptor interactions. It is also an invaluable resource for final year undergraduate and postgraduate students in pharmacology and cell and molecular biology. G Protein-Coupled Receptors: Molecular Pharmacology from Academic Concept to Pharmaceutical Research Vauquelin, Georges / Mentzer, Bengt Von, John Wiley & Sons

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G Protein-Coupled Receptors: Molecular Pharmacology from Academic Concept to Pharmaceutical Research - neues Buch

ISBN: 9780470516478

ID: 8467ebb71161686330733579b29e3ff0

Molecular Pharmacology G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly. G Protein-coupled Receptors - Molecular Pharmacology provides a clear summary of the current knowledge in this fast-evolving field. The book sets out with an introduction tosignalling molecules and their receptors, and an overview of the technical approaches used to investigate these interactions. Structural, functional and especially pharmacological aspects of GPCRs are then discussed in more detail and much attention is devoted to the analysis and interpretation of experimental data. The now widespread use of recombinant cell lines, receptor mutants and related artifices in drug research is critically evaluated. Special attention is also devoted to topical but often poorly understood concepts, such as insurmountable antagonism, inverse agonism and allosteric interactions. By combining general information with the major state-of-the-art concepts in GPCR research, the book equips the reader with the necessary background for understanding and critically evaluating the current literature. Written by two experts from academia and industry, G Protein-coupled Receptors -Molecular Pharmacology offers a unique view of academic and applied approaches aiming to reveal new ideas in pharmaceutical research. The book will be of interest to anyone involved in drug development and preclinical research and those who need to function within multi-disciplinary teams in the pharmaceutical industry: from investigators to product managers or clinicians who seek to have a broad mechanistic understanding of drug-receptor interactions. Final year undergraduate and postgraduate students in pharmacology and cell and molecular biology will also find the book an invaluable resource. Bücher / Fremdsprachige Bücher / Englische Bücher 978-0-470-51647-8, Wiley John + Sons

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G Protein-coupled Receptors - Vauquelin, Georges; von Mentzer, Bengt
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Georges Vauquelin. Department of Molecular and Biochemical Pharmacology, Free University Brussels (VUB), Belgium Bengt von Mentzer. Department of Molecular Pharmacology, AstraZeneca Inc, Sweden Technology Technology eBook, Wiley

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G Protein-coupled Receptors: Molecular Pharmacology Author :Bengt von Mentzer Georges Vauquelin 9780470516478 047051647X, [PU: Wiley]

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2007, ISBN: 9780470516478

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G Protein-Coupled Receptors: Molecular Pharmacology from Academic Concept to Pharmaceutical Research
Autor:

Vauquelin, Georges; Mentzer, Bengt Von

Titel:

G Protein-Coupled Receptors: Molecular Pharmacology from Academic Concept to Pharmaceutical Research

ISBN-Nummer:

047051647X

G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of utmost interest in drug development: over half of all prescription drugs currently on the market act by targeting these receptors directly or indirectly. G Protein-coupled Receptors - Molecular Pharmacology provides a clear summary of the current knowledge in this fast-evolving field. The book sets out with an introduction tosignalling molecules and their receptors, and an overview of the technical approaches used to investigate these interactions. Structural, functional and especially pharmacological aspects of GPCRs are then discussed in more detail and much attention is devoted to the analysis and interpretation of experimental data. The now widespread use of recombinant cell lines, receptor mutants and related artifices in drug research is critically evaluated. Special attention is also devoted to topical but often poorly understood concepts, such as insurmountable antagonism, inverse agonism and allosteric interactions. By combining general information with the major state-of-the-art concepts in GPCR research, the book equips the reader with the necessary background for understanding and critically evaluating the current literature. Written by two experts from academia and industry, G Protein-coupled Receptors -Molecular Pharmacology offers a unique view of academic and applied approaches aiming to reveal new ideas in pharmaceutical research. The book will be of interest to anyone involved in drug development and preclinical research and those who need to function within multi-disciplinary teams in the pharmaceutical industry: from investigators to product managers or clinicians who seek to have a broad mechanistic understanding of drug-receptor interactions. Final year undergraduate and postgraduate students in pharmacology and cell and molecular biology will also find the book an invaluable resource.

Detailangaben zum Buch - G Protein-Coupled Receptors: Molecular Pharmacology from Academic Concept to Pharmaceutical Research


EAN (ISBN-13): 9780470516478
ISBN (ISBN-10): 047051647X
Gebundene Ausgabe
Erscheinungsjahr: 2007
Herausgeber: John Wiley & Sons
252 Seiten
Gewicht: 0,687 kg
Sprache: eng/Englisch

Buch in der Datenbank seit 22.02.2008 22:59:15
Buch zuletzt gefunden am 23.11.2016 22:13:34
ISBN/EAN: 047051647X

ISBN - alternative Schreibweisen:
0-470-51647-X, 978-0-470-51647-8

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